Immunogenetic Interactions: Assessing the Capacity of Northern Species to Adapt to Infectious Disease

免疫遗传学相互作用：评估北方物种适应传染病的能力

• 批准号: RGPIN-2016-05373
• 负责人: Kyle, Christopher
• 金额: $ 2.26万
• 依托单位: Trent University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=628862
• 关键词: Immunogenetic; Interactions; Assessing; Capacity; Northern

Disease dynamics are rapidly being altered by climatic changes, with pathogens colonizing previously inhospitable/inaccessible environments as evidenced by several emerging diseases. My research program is interested in the adaptive potential of species to respond to disease with the overarching objective of predicting and mitigating threats to biodiversity. The current proposal investigates the capacity of species to adapt to disease by performing comprehensive scans of genetic variation associated with an immune response. Specifically, I aim to answer the following questions:

气候变化正在迅速改变疾病动态，病原体在以前不适宜居住/无法进入的环境中定居，几种新出现的疾病就是证明。我的研究计划是在物种的适应潜力，以预测和减轻对生物多样性的威胁的总体目标，以应对疾病感兴趣。目前的提案通过对与免疫反应相关的遗传变异进行全面扫描来调查物种适应疾病的能力。具体而言，我打算回答以下问题：