Capacity for Local Adaptation to Disease in Holarctic Species

全北极物种对疾病的局部适应能力

• 批准号: RGPIN-2015-05457
• 负责人: Kyle, Christopher
• 金额: $ 2.19万
• 依托单位: Trent University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=590440
• 关键词: Capacity; Local; Adaptation; Disease; Holarctic

Understanding mechanisms of wildlife disease maintenance and spread are of practical importance as they interrelate to human, wildlife and ecosystem health (e.g., recent Ebola outbreak). My research will investigate interactions between host and pathogen neutral and functional genetic variation across landscapes to understand patterns of disease spread and the capacity for host populations to adapt to disease. Arctic rabies (AR) provides a model system to understand the capacity for northern species to respond to rapid changes in disease patterns where climatic changes are having a pronounced effect on the dynamics of AR. The AR system includes multiple hosts with contrasting patterns of disease susceptibility and temporal disease exposure, making it possible to test hypotheses regarding the genetic interactions of AR with its hosts. Further, this system presents contrasts in the localization and spread of disease across its circumpolar distribution. This research will enhance our understanding mechanisms of wildlife disease spread and has the potential to help mitigate negative human and wildlife health impacts from wildlife disease.

了解野生动物疾病维持和传播的机制具有实际意义，因为它们与人类、野生动物和生态系统健康相互关联（例如，最近的埃博拉疫情）。我的研究将调查不同地区宿主和病原体之间的中性和功能性遗传变异之间的相互作用，以了解疾病传播的模式和宿主群体适应疾病的能力。北极狂犬病 (AR) 提供了一个模型系统，用于了解北方物种对疾病模式快速变化的反应能力，其中气候变化对 AR 动态产生显着影响。 AR 系统包括多个宿主，这些宿主具有不同的疾病易感性和暂时的疾病暴露模式，从而可以测试有关 AR 与其宿主的遗传相互作用的假设。此外，该系统在其环极分布中的疾病定位和传播方面呈现出对比。这项研究将增强我们对野生动物疾病传播机制的理解，并有可能帮助减轻野生动物疾病对人类和野生动物健康的负面影响。