In vivo imaging of neurovascular coupling

神经血管耦合的体内成像

• 批准号: 371884-2009
• 负责人: Stefanovic, Bojana
• 金额: $ 1.75万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=497807
• 关键词: vivo; imaging; neurovascular; coupling

Functional magnetic resonance imaging has greatly enhanced our understanding of how human brain processes information. In particular, while it is well established that brain activity is associated with local changes in brain blood flow that MRI can detect, the mechanism that links brain activity to blood flow is not well understood. Since blood flow adjustments in response to brain activity changes are critical for healthy brain function, different aspects of this coupling have become the focus of many recent studies. However, there are still very little data available on this topic in the live mammalian brain, the model most pertinent to our understanding of human brain function. In the proposed research, we will perform detailed microscopic imaging in live transgenic mice, as to further our understanding of the cellular processes that underlie the link between blood circulation and activity in the brain. In addition, this research will enhance the experimental tools and methodologies for the study of brain function in live mammals and aid in the interpretation of brain activation patterns observed in humans via functional MRI.

功能性磁共振成像极大地增强了我们对人类大脑如何处理信息的理解。特别是，虽然已经确定大脑活动与MRI可以检测到的脑血流量局部变化有关，但将大脑活动与血流量联系起来的机制尚未得到很好的理解。由于响应大脑活动变化的血流调节对健康的大脑功能至关重要，因此这种耦合的不同方面已成为许多最近研究的焦点。然而，在活体哺乳动物的大脑中，关于这一主题的数据仍然很少，而活体哺乳动物的大脑模型与我们对人类大脑功能的理解最为相关。在拟议的研究中，我们将对活的转基因小鼠进行详细的显微成像，以进一步了解血液循环和大脑活动之间联系的细胞过程。此外，本研究将为活体哺乳动物脑功能研究提供实验工具和方法，并有助于解释通过功能性MRI观察到的人类脑激活模式。