The roles of Rho GTPase family signalling in C.elegans

Rho蛋白家族通过控制大量活细胞的大小、形状和运动，在生物学中发挥着至关重要的调节作用。这一蛋白质家族的不适当活性被认为会导致人类疾病，它们在细胞生物学中扮演着重要的角色。虽然我们对这些蛋白质的一些简单功能有很好的了解，但我们不知道的是：(I)它们是如何调节的，(Ii)一旦它们被激活，它们结合了哪些其他蛋白质，以及(Iii)这些其他蛋白质是如何受到影响来发挥其生物学功能的。

The Rho-family of proteins play crucial regulatory roles in biology by controlling the size, shape and movements of a large number of living cells. Inappropriate activity of this family of proteins is known to lead to human diseases and they play a fundamental role in cell biology. Although we have a good understanding of some simple functions of these proteins, some things we do not know are (i) how are they regulated, (ii) once they are switched on, what other proteins do they bind and (iii) how are these other proteins affected to carry out their biological functions.