The roles of Rho GTPase family signalling in C.elegans

Rho GTPase 家族信号传导在秀丽隐杆线虫中的作用

• 批准号: 342190-2008
• 负责人: Kubiseski, Terrance
• 金额: $ 2.19万
• 依托单位: York University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=498048
• 关键词: roles; Rho; GTPase; family; signalling

The Rho-family of proteins play crucial regulatory roles in biology by controlling the size, shape and movements of a large number of living cells. Inappropriate activity of this family of proteins is known to lead to human diseases and they play a fundamental role in cell biology. Although we have a good understanding of some simple functions of these proteins, some things we do not know are (i) how are they regulated, (ii) once they are switched on, what other proteins do they bind and (iii) how are these other proteins affected to carry out their biological functions.

Rho蛋白家族通过控制大量活细胞的大小、形状和运动，在生物学中发挥着至关重要的调节作用。 已知该蛋白质家族的不适当活性会导致人类疾病，并且它们在细胞生物学中起着重要作用。 虽然我们对这些蛋白质的一些简单功能有了很好的了解，但我们不知道的是：（i）它们是如何被调节的;（ii）一旦它们被打开，它们会结合哪些其他蛋白质;（iii）这些其他蛋白质是如何被影响以实现其生物学功能的。