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The roles of Rho GTPase family signalling in C.elegans

The roles of Rho GTPase family signalling in C.elegans
Rho GTPase 家族信号传导在秀丽隐杆线虫中的作用
批准号:
342190-2008
负责人:
Kubiseski, Terrance
金额:
$2.19万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2012
资助国家:
加拿大
项目状态:
已结题
起止时间:
2012-01-01 至 2013-12-31

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英文摘要
The Rho-family of proteins play crucial regulatory roles in biology by controlling the size, shape and movements of a large number of living cells. Inappropriate activity of this family of proteins is known to lead to human diseases and they play a fundamental role in cell biology. Although we have a good understanding of some simple functions of these proteins, some things we do not know are (i) how are they regulated, (ii) once they are switched on, what other proteins do they bind and (iii) how are these other proteins affected to carry out their biological functions.
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