Model-based prediction of mastication and swallowing outcomes for head and neck surgery

基于模型的头颈手术咀嚼和吞咽结果预测

• 批准号: 414167-2012
• 负责人: Fels, Sidney
• 金额: $ 6.48万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=503891
• 关键词: Model; based; prediction; mastication; swallowing

Three-dimensional computer modeling of anatomical structures is an indispensable tool for surgical planning. An outstanding example is reconstruction of the jaws that is a complex geometric surgery. The microvascular fibular free flap is the workhorse for jaw reconstruction and is internationally pervasive for management of head/neck cancer, trauma and certain congenital defects. Geometric modeling methods have greatly improved the geometric (anatomical) predictability of these complex microvascular reconstructive procedures. They have also enabled the introduction of surgical innovations that reduce treatment time remarkably, from 2-4 years down to 12 weeks. The endpoint of these procedures is to improve functional outcomes of care. However, geometric modeling is static, and cannot predict functional outcomes such as how effectively a patient will chew or swallow. These outcomes enormously impact patient's quality of life, with swallowing deficits producing significant risk of morbidity and mortality due to aspiration. Thus, we propose creating dynamic, 3D, patient-specific computer models of oral and upper airway anatomy to predict functional mastication and swallowing outcomes for head and neck surgery. Our predictions will optimize functional outcomes through simulation and design of surgery, surgical guides, prostheses and implant installation. Our project will also provide the science and tools to enable dynamic biomechanical modeling used for other surgical procedures besides jaw reconstruction. We have assembled a world-class interdisciplinary team of investigators, collaborators and knowledge transfer users, with proven technical expertise, track record and ability to work together for this project.

解剖结构的三维计算机建模是外科手术规划不可缺少的工具。一个突出的例子是颌骨重建，这是一项复杂的几何手术。微血管腓骨瓣是颌骨重建的主力军，在国际上广泛应用于头颈部癌症、创伤和某些先天缺陷的治疗。几何建模方法极大地提高了这些复杂的微血管重建过程的几何(解剖)可预测性。它们还使外科创新得以引入，显著缩短了治疗时间，从2-4年减少到12周。这些程序的目的是改善护理的功能结果。然而，几何建模是静态的，不能预测功能结果，如患者咀嚼或吞咽的效果如何。这些结果极大地影响了患者的生活质量，吞咽缺陷会产生因误吸而导致的发病率和死亡率的巨大风险。因此，我们建议创建动态的、3D的、特定于患者的口腔和上呼吸道解剖的计算机模型，以预测头颈部手术的功能性咀嚼和吞咽结果。我们的预测将通过模拟和设计手术、手术导向、假体和植入物安装来优化功能结果。我们的项目还将提供科学和工具，使动态生物力学建模能够用于除颌骨重建之外的其他外科手术。我们已经组建了一支由调查人员、合作者和知识转移用户组成的世界级跨学科团队，他们拥有经过验证的技术专长、过往记录和为这个项目共同工作的能力。