Regulating viral protein production and stability using small molecules

点击翻译按钮获取中文摘要

Viruses are remarkably selective and efficient nucleic acid delivery devices that serve as excellent model systems for studying complex protein assemblies as well as core cellular functions. Some of the most complicated and poorly understood viruses are the members of the Herpesviridae. In the case of the model herpesvirus studied in our laboratory, herpes simplex virus type 2, the viruses are built from about 100 different proteins. A focus of research in the Banfield laboratory is to understand the mechanisms by which these fascinating structures assemble.