Remodeling of the nuclear membrane during herpesvirus assembly

疱疹病毒组装过程中核膜的重塑

• 批准号: RGPIN-2017-04194
• 负责人: Banfield, Bruce
• 金额: $ 2.04万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629280
• 关键词: Remodeling; nuclear; membrane; during; herpesvirus

Much of what we understand about the fundamental processes that enable cells to proliferate and to perform specific biological functions has come from the study of virus-host cell interactions. This fact is, in part, due to the ability of viruses to redirect key cellular processes away from their intended cellular functions towards building thousands of new virus particles comprised of relatively few components. These viral components are often produced in abundance, making the cellular processes that they influence easier to study than if one was investigating these processes in non-infected cells.

我们对细胞增殖和执行特定生物功能的基本过程的理解，大部分来自对病毒-宿主细胞相互作用的研究。这一事实部分是由于病毒能够将关键的细胞过程从其预期的细胞功能转向构建数千个由相对较少的组分组成的新病毒颗粒。这些病毒成分通常大量产生，使得它们影响的细胞过程比在未感染细胞中研究这些过程更容易研究。