"Investigation into the dynamics of toxicity using a novel, first-principles based semantic biochemical reactor."

“使用一种新颖的、基于第一原理的语义生化反应器来研究毒性动力学。”

• 批准号: 327371-2012
• 负责人: Dumontier, Michel
• 金额: $ 1.46万
• 依托单位: Carleton University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=506256
• 关键词: Investigation; into; dynamics; toxicity; using

Chemicals, whether found in food products, commercial goods or pharmaceutical formulations, can be toxic because they adversely affect normal functions. Humans, like other animals, have an ability to metabolize xenochemicals into other forms that make them easier to eliminate, but they can be even more toxic. An increased understanding of the toxicity of metabolic products could help assess environmental risk and inform regulations to improve safety.

化学品，无论是存在于食品、商业商品还是药品配方中，都可能是有毒的，因为它们会对正常功能造成不利影响。像其他动物一样，人类有能力将外来化学物质代谢成其他形式，使它们更容易消除，但它们的毒性可能更大。增加对代谢产品毒性的了解可以帮助评估环境风险，并为提高安全性的法规提供信息。