An investigation into chromatin dynamics in host-pathogen interactions and fungal virulence

宿主-病原体相互作用和真菌毒力中染色质动力学的研究

• 批准号: nhmrc : GNT1138812
• 负责人: A/Pr Ana Traven
• 金额: $ 70.06万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/an-investigation-chromatin-fungal-virulence/1348184
• 关键词: investigation; into; chromatin; dynamics; host

Fungal infections represent a major health burden, with loss of lives that parallels malaria. Only a handful of antifungal therapeutics is available, and mortality remains very high (30% or more). By using molecular biology approaches and animal infection models, this project aims to characterize a new class of promising antifungal drug targets in the major human fungal pathogen Candida albicans. The outcomes will provide the knowledge foundation for future antifungal drug discovery.

真菌感染是一项重大的健康负担，造成的生命损失与疟疾相当。只有少数几种抗真菌疗法可用，死亡率仍然很高（30%或更多）。通过分子生物学方法和动物感染模型，本项目旨在描述一类新的有希望的抗真菌药物靶点在主要的人类真菌病原体白色念珠菌。研究结果将为今后抗真菌药物的开发提供知识基础。