An investigation into chromatin dynamics in host-pathogen interactions and fungal virulence

真菌感染是一个主要的健康负担，与疟疾类似的生命损失。只有少数几种抗真菌药物可用，死亡率仍然很高(30%或更高)。通过分子生物学方法和动物感染模型，本项目旨在表征人类主要真菌病原体白色念珠菌中一类新的有希望的抗真菌药物靶点。这一结果将为未来抗真菌药物的开发提供知识基础。

Fungal infections represent a major health burden, with loss of lives that parallels malaria. Only a handful of antifungal therapeutics is available, and mortality remains very high (30% or more). By using molecular biology approaches and animal infection models, this project aims to characterize a new class of promising antifungal drug targets in the major human fungal pathogen Candida albicans. The outcomes will provide the knowledge foundation for future antifungal drug discovery.