Capillary differential scanning calorimeter

我们正在为毛细管差示扫描量热仪(DSC)申请资金；该仪器是一种强大的工具，用于测量所有主要类别的生物分子，包括蛋白质、核酸、脂类和碳水化合物以及金属离子等较小配体的结构转变和结合作用所引起的能量变化。因此，差示扫描量热法是分析支配大量生物分子体系结构和功能的能量学的独特而宝贵的工具。理解这些能量学对于操纵和控制这些系统在自然界、生物技术和医学中的行为是至关重要的。虽然在定义生物分子能量学方面已经取得了令人振奋的进展，但我们仍然有很多工作要做，才能达到准确、可预测地理解生物分子结构和功能的最终目标。

We are requesting funding for a capillary differential scanning calorimeter (DSC); this instrument is a powerful tool for measuring the changes in energy associated with structural transitions and binding interactions for all the major classes of biomolecules, including proteins, nucleic acids, lipids and carbohydrates, as well as smaller ligands, such as metal ions. Thus, DSC is a unique and invaluable tool for analyzing the energetics governing the structure and function of a huge range of biomolecule systems. The understanding of such energetics is essential for manipulating and controlling the behaviour of these systems, in nature, biotechnology and medicine. While there has been exciting progress in defining biomolecule energetics, we still have much work to do to reach the ultimate goal of an accurate, predictive understanding of biomolecule structure and function.