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Supramolecular recognition in water by Cucurbituril hosts

Supramolecular recognition in water by Cucurbituril hosts
葫芦脲宿主在水中的超分子识别
批准号:
37148-2010
负责人:
Macartney, Donal
金额:
$2.91万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2012
资助国家:
加拿大
项目状态:
已结题
起止时间:
2012-01-01 至 2013-12-31

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中文摘要
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英文摘要
This research program involves the investigations of the chemistry and potential applications of cucurbit[n]urils (CB[n]), a family of host molecules, which display remarkably strong and selective binding to a variety of guest molecules in water, using the hydrophobic property of the host's cavity and non-covalent ion-dipole and dipole-dipole interactions at the polar and restrictive portals to the cavity. Molecular recognition of guest molecules by host molecules in aqueous solution, an important feature of numerous substrate-enzyme interactions in Nature, will be of increasing future interest in areas such as Green Chemistry, drug design, and drug delivery.
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Selective Molecular Recognition of Biological and Medicinal Guests in Water by Cucurbit[n]uril Hosts
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