Supramolecular recognition in water by Cucurbituril hosts

葫芦脲宿主在水中的超分子识别

• 批准号: 37148-2010
• 负责人: Macartney, Donal
• 金额: $ 2.91万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=450706
• 关键词: Supramolecular; recognition; water; Cucurbituril; hosts

This research program involves the investigations of the chemistry and potential applications of cucurbit[n]urils (CB[n]), a family of host molecules, which display remarkably strong and selective binding to a variety of guest molecules in water, using the hydrophobic property of the host's cavity and non-covalent ion-dipole and dipole-dipole interactions at the polar and restrictive portals to the cavity. Molecular recognition of guest molecules by host molecules in aqueous solution, an important feature of numerous substrate-enzyme interactions in Nature, will be of increasing future interest in areas such as Green Chemistry, drug design, and drug delivery.

本研究项目涉及葫芦[n]urils （CB[n]）的化学研究和潜在应用。葫芦[n]urils （CB[n]）是一类寄主分子，利用寄主空腔的疏水性和非共价离子-偶极子和偶极子-偶极子相互作用，在极性和限制性的空腔入口上，与水中的各种客体分子表现出非常强的选择性结合。水溶液中宿主分子对客体分子的分子识别是自然界中许多底物-酶相互作用的一个重要特征，未来将在绿色化学、药物设计和药物递送等领域引起越来越多的兴趣。