Supramolecular recognition in water by Cucurbituril hosts

葫芦脲宿主在水中的超分子识别

• 批准号: 37148-2010
• 负责人: Macartney, Donal
• 金额: $ 2.91万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=474757
• 关键词: Supramolecular; recognition; water; Cucurbituril; hosts

This research program involves the investigations of the chemistry and potential applications of cucurbit[n]urils (CB[n]), a family of host molecules, which display remarkably strong and selective binding to a variety of guest molecules in water, using the hydrophobic property of the host's cavity and non-covalent ion-dipole and dipole-dipole interactions at the polar and restrictive portals to the cavity. Molecular recognition of guest molecules by host molecules in aqueous solution, an important feature of numerous substrate-enzyme interactions in Nature, will be of increasing future interest in areas such as Green Chemistry, drug design, and drug delivery.

本研究计划涉及葫芦[n]脲（CB[n]）的化学和潜在应用的调查，一个家庭的主机分子，显示出显着的强大和选择性的结合到各种客体分子在水中，使用主机的腔和非共价离子的疏水性偶极和偶极偶极相互作用的极性和限制性门户的腔。 在水溶液中，客体分子与主体分子的分子识别是自然界中许多底物-酶相互作用的重要特征，将在诸如绿色化学、药物设计和药物递送等领域引起越来越多的兴趣。