Electromagnetic measurement system for intravascular motion compensation

血管内运动补偿电磁测量系统

• 批准号: 437826-2013
• 负责人: Duong, Luc
• 金额: $ 1.6万
• 依托单位: École de technologie supérieure
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=507842
• 关键词: Electromagnetic; measurement; system; intravascular; motion

This research grant proposal aimed at providing motion compensation during percutaneous coronary interventions. A novel image-based motion compensation technique was recently proposed from our research group, based on a monoplane X-ray angiography sequence. A validation was conducted using simulated results and offline clinical datasets, but a validation in 3D is still required. Validation of 2D image-based motion compensation is difficult, since no ground truth motion in 3D is available during the intervention to compare against. An electromagnetic measurement system (EMS) for real-time intravascular navigation would provide an adequate means to validate of our motion compensation technique. This EMS would provide real-time 6 degrees of freedom spatial measurements of elongated structures representing coronary arteries under a certain motion. A custom mounted magnetic tracked guide wire, inserted through a catheter inside a coronary phantom, will provide real-time measurements. Realtime measurements would provide an optimal means of validating the predicted motion from X-ray angiography. The EMS measurement system would provide a ground truth from which our proposed image-based motion compensation can be compared against. This will be helpful for our graduate students to develop a rigorous approach for data validation and scientific objectivity both necessary in medical imaging research. Moreover, this research instrumentation will be used for other intravascular research projects such as OCT and IVUS imaging requiring real time 3D positions for validation purpose. Advanced visualization tools of medical image data are paramount to ensure safe navigation during PCI. However, PCI remains highly challenging since cardiologists must rely on occasional contrast injection to assess coronary topology in 2D. Image registration of preoperative 3D image with 2D online X-ray imaging would be helpful for navigation guidance. This grant application is aimed at supporting an individual NSERC Discovery Grant 2010 to 2014.

这项研究资助提案旨在经皮冠状动脉介入治疗期间提供运动补偿。本课题组最近提出了一种基于图像的运动补偿技术，该技术基于单平面X射线血管造影序列。使用模拟结果和离线临床数据集进行了确认，但仍需要进行3D确认。基于2D图像的运动补偿的验证是困难的，因为在介入期间没有3D中的地面实况运动可用于比较。用于实时血管内导航的电磁测量系统（EMS）将提供足够的手段来验证我们的运动补偿技术。该EMS将提供在特定运动下代表冠状动脉的细长结构的实时6自由度空间测量。通过冠状动脉体模内的导管插入定制安装的磁性跟踪导丝，将提供实时测量。实时测量将提供验证来自X射线血管造影术的预测运动的最佳手段。EMS测量系统将提供地面实况，我们提出的基于图像的运动补偿可以与之进行比较。 这将有助于我们的研究生制定一个严格的方法，数据验证和科学的客观性都需要在医学成像研究。此外，该研究仪器将用于其他血管内研究项目，如OCT和IVUS成像，这些项目需要真实的实时3D位置进行确认。 医学图像数据的高级可视化工具对于确保PCI期间的安全导航至关重要。然而，PCI仍然极具挑战性，因为心脏病专家必须依靠偶尔注射造影剂来评估2D中的冠状动脉拓扑结构。术前3D图像与2D在线X射线成像的图像配准将有助于导航引导。该补助金申请旨在支持2010年至2014年的个人NSERC发现补助金。