Innovative approaches using biological systems and processes for mitigating the challenges in biotechnology and the environment

利用生物系统和工艺缓解生物技术和环境挑战的创新方法

• 批准号: 170124-2011
• 负责人: Bassi, Amarjeet
• 金额: $ 2.91万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=510015
• 关键词: Innovative; approaches; using; biological; systems

New challenges have emerged for humanity in the 21st century which include "carbon capture", "nitrogen cycle and nutrient management", "clean and safe water" and "engineering better medicines and technology" as some of the significant issues of concern. In addition to the environmental and societal benefits, better and novel solutions to these specific challenges can lead to the generation of new industry, spin-offs, jobs and other activities over both the short and long term. In this proposed research program, which builds on existing research strengths, and the principles of biochemical and bio-environmental engineering, innovative approaches are proposed in the areas of health, nutrient management and clean water. Three specific projects are proposed. The first project utilizes a fluidized ion exchange technology as an alternative approach to overcome challenges related to the refolding of recombinant proteins. The second project focuses on removal of nutrients (ammonium, nitrates and phosphates) using a combination of ion exchange and halophilic microalgae. The third project addresses the important and difficult area of metal removal from saline waste waters and proposes to initiate a new direction of research at UWO with significant potential to address the issues of "clean and safe water". The proposed research will train 6 HQP (4 PhD and 2 MESc) over the duration of this study. The proposed research has potential to attract new funding and collaborations from Industry and other government agencies both nationally and Internationally.

21世纪人类面临的新挑战包括“碳捕获”、“氮循环和养分管理”、“清洁和安全的水”以及“设计更好的药物和技术”，这是一些值得关注的重大问题。除了环境和社会效益外，针对这些具体挑战的更好和新颖的解决方案可以在短期和长期内催生新的产业、衍生产品、就业机会和其他活动。在这项拟议的研究计划中，它建立在现有的研究优势以及生物化学和生物环境工程的原则基础上，在健康、营养管理和清洁水领域提出了创新方法。提出了三个具体项目。第一个项目利用流态化离子交换技术作为克服重组蛋白重折叠相关挑战的替代方法。第二个项目侧重于结合离子交换和嗜盐微藻去除营养物（铵、硝酸盐和磷酸盐）。第三个项目涉及从含盐废水中去除金属这一重要而困难的领域，并建议在沃沃大学开展一个新的研究方向，该方向具有解决“清洁和安全水”问题的巨大潜力。拟议的研究将在研究期间培养6名HQP（4名博士和2名MESc）。拟议中的研究有可能吸引来自国内外工业界和其他政府机构的新资金和合作。