Advanced Orthopedic Coating

先进的矫形涂层

• 批准号: 429339-2012
• 负责人: Krstic, Vladimir
• 金额: $ 1.82万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=510915
• 关键词: Advanced; Orthopedic; Coating

Poly-ether-ether-ketone, commonly known as PEEK, is a high performance engineering thermoplastic. However, it has been shown to be relatively inert in a biological context, and so over the past decade there has been interest in using the PEEK polymer for load-bearing orthopaedic applications. Unfortunately, its inert chemical property causes it to be hydrophobic and so cannot be directly involved in the cellular activity normal to a healthy orthopaedic environment. A further disadvantage is that it is x-ray transparent so orthopaedic use is compromised by the fact that the surgeon cannot easily check on the placement of a prosthesis by conventional x-rays as used in a hospital. The supporting organization in this 'Engage' application, has been attempting to remedy both of these deficiencies but has only been able to report partial success. This application seeks to achieve the desired level of success by attaching a coating which will enable the prosthesis to be seen in an x-radiograph and which will be sufficiently hydrophilic to support the cellular processes required in the generation of new bone.

聚醚醚酮，俗称PEEK，是一种高性能的工程热塑性塑料。然而，已证明其在生物学背景下相对惰性，因此在过去十年中，人们对将PEEK聚合物用于承重骨科应用产生了兴趣。不幸的是，它的惰性化学性质导致它是疏水性的，因此不能直接参与健康骨科环境中正常的细胞活性。另一个缺点是它是X射线透明的，因此整形外科的使用受到以下事实的影响，即外科医生不能通过医院中使用的常规X射线容易地检查假体的放置。在这个“参与”应用程序中的支持组织一直在尝试补救这两个缺陷，但只能报告部分成功。该申请试图通过附着涂层来实现所需的成功水平，该涂层将使假体能够在X射线照片中被看到，并且该涂层将具有足够的亲水性以支持新骨生成所需的细胞过程。