Development of prototype test strips for home-use BNP detection

这项提议是为了开发一种原型测试条，它集成了完全基于碳纳米管的免疫传感器和微流控通道。其目的是验证使用由简单电子设备操作的试纸快速检测一滴血中脑利钠肽(BNP)水平的可行性。BNP是一种非常有用的血液分子标志物，可用于心力衰竭的诊断和预后。由此产生的技术最终可能导致家庭使用的BNP监测系统，类似于常用的血糖仪。目前还没有家庭使用的BNP测试。该项目是滑铁卢大学唐的生物纳米小组与Mespere生命科学公司的首次联合研发工作，Mespere生命科学公司是对心血管疾病早期诊断和治疗至关重要的监测技术的先驱。唐集团将为拟议的试条的建设贡献关键的使能技术，梅斯佩雷将贡献医疗器械工程方面的专业知识，并协助对照FDA批准的参考文献进行验证。

This proposal is for the development of a prototype test strip, which integrates fully electrical carbon nanotube based immunosensors and microfluidic channels. The goal is to validate the feasibility of using the test strip, operated by simple electronics, to rapidly detect brain natriuretic peptide (BNP) levels in a drop of blood. BNP is a very useful molecular marker in blood for the diagnosis and prognosis of heart failure. The resulted technology could ultimately lead to home-use BNP monitoring systems, similar to the commonly used blood glucose meters. There is no home-use BNP test available currently. This project is the first joint R & D effort by Tang's BIONANO group at University of Waterloo and Mespere Lifesciences, a company pioneering monitoring technologies critical to early diagnosis and treatment of cardiovascular diseases. The Tang group will contribute key enabling technologies for the construction of the proposed test strip and Mespere will contribute expertise in medical device engineering and assist in the validation against FDA approved references.