Tools to increase risk assessment accuracy of lead and mercury in contaminated soils

提高受污染土壤中铅和汞风险评估准确性的工具

• 批准号: 445875-2012
• 负责人: Weber, Lynn
• 金额: $ 1.82万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=511527
• 关键词: Tools; increase; risk; assessment; accuracy

Risklogic is an environmental consulting company specializing in management and analysis of contaminated industrial sites. They are experts in remediating sites that are contaminated with multiple heavy metals and have developed a novel method for simplifying how risky these sites really are to both wildlife and humans. However, their method requires experimental validation of two assumptions. First, that the effects of metals cause toxicity through the same mechanism and second, that the effects are additive. In order to test these assumptions, we propose that lead, inorganic mercury and organic mercury all cause cardiovascular effects (e.g. high blood pressure) by increasing oxidative stress or through epigenetic mechanisms. We will test these assumptions using rats exposed in drinking water to these metals, both alone and together. Finally, we will examine whether there are any sex differences in responses. Validating Risklogic's model will accelerate the process and reduce remediation costs associated with urban brownfields which in turn will reduce the costs to companies responsible for cleanup, decrease economic burden and help improve the Canadian economy.

Risklogic是一家专门从事污染工业场所管理和分析的环境咨询公司。他们是修复被多种重金属污染场地的专家，并开发了一种新的方法来简化这些场地对野生动物和人类的真正风险。然而，他们的方法需要对两个假设进行实验验证。第一，金属的作用通过同样的机制引起毒性，第二，这些作用是加性的。为了验证这些假设，我们提出铅、无机汞和有机汞都通过增加氧化应激或通过表观遗传机制引起心血管影响（如高血压）。我们将用老鼠来测试这些假设，让它们单独或一起暴露在这些金属的饮用水中。最后，我们将研究在反应中是否存在性别差异。验证Risklogic的模型将加速这一过程，降低与城市棕地相关的修复成本，从而降低负责清理的公司的成本，减轻经济负担，并有助于改善加拿大经济。