Applications of nanotechnology to biophysical chemistry

纳米技术在生物物理化学中的应用

• 批准号: 203312-2008
• 负责人: Cramb, David
• 金额: $ 3.79万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=514105
• 关键词: Applications; nanotechnology; biophysical; chemistry

Increasingly, semi-conductor nanocrystals (aka quantum dots, QDs) are being used in biophysical research. The applications are mostly to enhance imaging analyses of tissues and in biological assays of ligand binding and protein or genetic material dynamics. The dots' narrow luminescence spectra and almost infinite photostability suggest that they are the ultimate fluorescent label. However, crucial aspects of the photophysical and photodynamic behavior of quantum dots remain poorly understood. Once a deeper understanding of this behavior is gained, it will be possible to exploit more thoroughly the application of quantum dots in nanodevices for biophysical research, a research paradigm which is in its infancy.

越来越多的半导体纳米晶体（又名量子点，QD）被用于生物物理研究。其应用主要是增强组织的成像分析，以及配体结合和蛋白质或遗传物质动力学的生物测定。量子点的窄发光光谱和几乎无限的光稳定性表明它们是最终的荧光标记。然而，量子点的光物理和光动力学行为的关键方面仍然知之甚少。一旦对这种行为有了更深入的了解，就有可能更彻底地利用量子点在纳米器件中的应用进行生物物理研究，这是一种处于起步阶段的研究范式。