Surface feature characterization and expression analysis of protein interactions

蛋白质相互作用的表面特征表征和表达分析

• 批准号: 262024-2008
• 负责人: McConkey, Brendan
• 金额: $ 2.92万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=514638
• 关键词: Surface; feature; characterization; expression; analysis

High-throughput proteomics experiments and structural genomics efforts are generating a huge amount of interaction and structural data, but it will not be feasible or possible to characterize all biomolecular interactions at the level of structure. Effective means of modeling will be required for the majority of interactions of interest. The proposed research will develop methods to effectively model a target group of protein-protein interactions, and has the larger goal of developing methods for predicting any interaction. Many protein-protein interactions are mediated by one structure recognizing a particular peptide sequence, often in a loop or unstructured region of the second protein. If this is the case, a recognition method that can dock a structured protein to an unstructured region will be needed to identify many relevant biological interactions. The proposed research addresses this problem.

高通量蛋白质组学实验和结构基因组学研究正在产生大量的相互作用和结构数据，但在结构水平上表征所有生物分子相互作用是不可行或不可能的。对于大多数感兴趣的相互作用，将需要有效的建模手段。拟议的研究将开发有效模拟蛋白质-蛋白质相互作用目标组的方法，并具有开发预测任何相互作用的方法的更大目标。 许多蛋白质-蛋白质相互作用由识别特定肽序列的一个结构介导，通常在第二个蛋白质的环或非结构化区域中。如果是这种情况，将需要一种能够将结构化蛋白质停靠到非结构化区域的识别方法来识别许多相关的生物相互作用。拟议的研究解决了这个问题。