Mechanisms and implications of two-component signal transduction in Campylobacter jejuni

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The ability of bacteria to sense and respond to different conditions is essential to their survival. A conserved means to enact this is the two-component signal transduction system (TCS). In typical two-component systems, a sensor protein on the bacterial surface senses an external signal and activates a regulator protein in the cytoplasm. The regulator then binds DNA to alter gene expression, which in turn alters bacterial behavior in response to the signal.