Mechanisms and implications of two-component signal transduction in Campylobacter jejuni

空肠弯曲菌双组分信号转导的机制和意义

• 批准号: 386667-2012
• 负责人: Gaynor, Erin
• 金额: $ 2.91万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=529005
• 关键词: Mechanisms; implications; two; component; signal

The ability of bacteria to sense and respond to different conditions is essential to their survival. A conserved means to enact this is the two-component signal transduction system (TCS). In typical two-component systems, a sensor protein on the bacterial surface senses an external signal and activates a regulator protein in the cytoplasm. The regulator then binds DNA to alter gene expression, which in turn alters bacterial behavior in response to the signal.

细菌对不同环境的感知和反应能力对它们的生存至关重要。实现这一目标的保守方法是双组分信号转导系统（TCS）。在典型的双组分系统中，细菌表面的传感蛋白感知外部信号并激活细胞质中的调节蛋白。然后，调节因子结合DNA来改变基因表达，进而改变细菌对信号的反应行为。