Novel regulators of granulosa cell function

颗粒细胞功能的新型调节剂

• 批准号: 106389-2010
• 负责人: Price, Christopher
• 金额: $ 2.19万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=522054
• 关键词: Novel; regulators; granulosa; cell; function

Fertility is dependent on successful development of a mature egg in the ovary. The egg develops in the follicle, and the overall aim of this research program is to understand more fully the control of ovarian follicle growth. Controlling fertility in cattle is particularly important for the dairy and beef industries in Canada, and the cow is also a useful model for humans, as cows have patterns of follicle growth that are similar to those seen in women. Follicle growth is regulated by a wide range of hormones and proteins, and in this project we will focus on two proteins recently described to play potential roles in the cow follicle. One of these is Fibroblast Growth Factor-18, which increases the number of dead cells within the follicle. We aim to determine how this protein causes the death of these cells. The second is Angiotensin, which is traditionally involved in regulation of blood pressure. We have evidence that Angiotensin may alter tissue remodelling in the ovary, and we shall explore the mechanism of this action. By gaining a clearer understanding of cell death and tissue growth in the follicle, we will be able to devise better methods for controlling fertility in agriculturally important species including ruminants.

生育能力取决于卵巢中成熟卵子的成功发育。卵子在卵泡内发育，本研究项目的总体目的是为了更全面地了解卵泡生长的控制。控制牛的生育能力对加拿大的乳制品和牛肉行业尤为重要，牛也是人类的有用模型，因为牛的毛囊生长模式与女性相似。卵泡的生长受多种激素和蛋白质的调节，在这个项目中，我们将重点介绍最近被描述为在奶牛卵泡中发挥潜在作用的两种蛋白质。其中之一是成纤维细胞生长因子-18，它增加了卵泡内死亡细胞的数量。我们的目标是确定这种蛋白质是如何导致这些细胞死亡的。第二种是血管紧张素，它传统上参与调节血压。我们有证据表明血管紧张素可以改变卵巢中的组织重塑，我们将探索这一作用的机制。通过更清楚地了解卵泡中的细胞死亡和组织生长，我们将能够设计出更好的方法来控制包括反刍动物在内的农业重要物种的生育能力。