Chemical Synthesis and Applications of Oligonucleotides and Analogs

寡核苷酸及其类似物的化学合成及应用

• 批准号: 203210-2012
• 负责人: Hudson, Robert
• 金额: $ 5.1万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=523394
• 关键词: Chemical; Synthesis; Applications; Oligonucleotides; Analogs

My research program is concerned with the development of structurally modified oligonucloetides (DNA and RNA) and non-natural oligonucleotide mimics such as peptide nucleic acid (PNA) that: (1) expand our understanding of the chemistry, function and biology of nucleic acids; (2) will serve as sequence probes and biomolecular tools for other areas of study; and (3) may act as artificial regulators of gene expression. Another area of research is dedicated to the designs, synthesis, understanding and application of contrast agents for medical imaging by magnetic resonance (MR).

我的研究项目涉及结构修饰的寡核苷酸（DNA和RNA）和非天然寡核苷酸模拟物（如肽核酸（PNA））的发展：（1）扩大我们对核酸的化学，功能和生物学的理解;（2）将作为其他研究领域的序列探针和生物分子工具;（3）可能作为基因表达的人工调节剂。 另一个研究领域致力于磁共振（MR）医学成像造影剂的设计、合成、理解和应用。