Understanding of insect odorant-binding proteins and cytochrome P450 mechanisms for the development of new insect behaviour control agents

了解昆虫气味结合蛋白和细胞色素 P450 机制，用于开发新型昆虫行为控制剂

• 批准号: 222923-2010
• 负责人: Plettner, Erika
• 金额: $ 3.64万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=523875
• 关键词: Understanding; insect; odorant; binding; proteins

Insects guide important behaviours for their survival through chemical signals. E. g., male gypsy moths detect the attractant pheromone emitted by the females or the odours of host plants, using their antennae. Hollow sensory hairs on the antennae contain nerve cell endings that are bathed by pheromone-binding proteins (PBPs). These PBPs are essential for the highly sensitive and selective signalling of the sensory hairs. Two PBPs in gypsy moth differ in their binding mechanism for various natural odorants or for synthetic olfaction modulators, discovered in the applicant's group. These modulators either decrease or enhance the response of the moths to a particular pheromone or plant odour. The first objective of this proposal aims to link the structure of the two PBPs and their cognate ligands with the electrophysiological responses of single sensory hairs. These responses can be linked to the behaviour of the insect. Such molecule-to-behaviour links are necessary for the optimization of compounds that modulate pest insect behaviour through their effect on the olfactory system.

昆虫通过化学信号指导重要的生存行为。E.例如，在一个实施例中，雄性舞毒蛾用触角探测雌性舞毒蛾散发的引诱信息素或寄主植物的气味。触角上的中空感觉毛含有被信息素结合蛋白（PBPs）浸泡的神经细胞末梢。 这些PBP对于感觉毛的高度敏感和选择性信号传导是必不可少的。舞毒蛾中的两种PBP在其对各种天然气味剂或合成嗅觉调节剂的结合机制方面不同，这是在申请人的小组中发现的。 这些调节剂降低或增强蛾对特定信息素或植物气味的反应。 该建议的第一个目标旨在将两个PBP及其同源配体的结构与单个感觉毛发的电生理反应联系起来。 这些反应可能与昆虫的行为有关。 这种分子与行为的联系对于通过其对嗅觉系统的作用来调节害虫昆虫行为的化合物的优化是必要的。