Defining the shape of evolutionary landscapes

定义进化景观的形状

• 批准号: 298397-2010
• 负责人: Blouin, Christian
• 金额: $ 1.82万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=526015
• 关键词: Defining; shape; evolutionary; landscapes

It is possible to infer the past by observing the diversity of genes that exist today only if we understand the mechanics of diversification. In the case of genes and their products, we call this diversification "evolution". We further represent the natural history of genes using phylogenetic trees: where each leaf is an observation, each bifurcation an assumed ancestor to its leaves, and the root being the last common ancestor to all leaves. This proposal is about the rigorous understanding of how the most likely tree can be found, and about the meaning of trees inferred from the 3D structures of proteins.

只有当我们理解多样性的机制时，才有可能通过观察今天存在的基因多样性来推断过去。就基因及其产物而言，我们称这种多样化为“进化”。我们进一步表示基因的自然历史，使用系统发育树：其中每个叶子是一个观察，每个分叉是其叶子的假定祖先，而根是所有叶子的最后共同祖先。这个提议是关于如何找到最有可能的树的严格理解，以及关于从蛋白质的3D结构推断出的树的意义。