Real-time proteomics on heterogeneous multi-core processors

异构多核处理器上的实时蛋白质组学

• 批准号: 327498-2009
• 负责人: Green, James
• 金额: $ 1.38万
• 依托单位: Carleton University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=526985
• 关键词: Real; time; proteomics; heterogeneous; multi

Tandem mass spectrometry (MS/MS) is an analytical technique for identifying proteins from an unknown mixture, and has become a cornerstone of modern proteomics. Currently, protein identification is relegated to take place offline, after the data collection phase, when it is too late to take corrective action in the case of an ambiguous identification. By sufficiently accelerating the data analysis, it becomes possible to close the feedback loop and achieve true hypothesis-driven data collection. This research program will result in new algorithms for spectral processing and protein identification to enable real-time control of a MS/MS device.

串联质谱（MS/MS）是一种从未知混合物中鉴定蛋白质的分析技术，已成为现代蛋白质组学的基石。目前，蛋白质鉴定被降级为离线进行，在数据收集阶段之后，在鉴定不明确的情况下采取纠正措施为时已晚。通过充分加速数据分析，可以关闭反馈回路并实现真正的假设驱动数据收集。该研究项目将产生用于光谱处理和蛋白质鉴定的新算法，从而实现对质谱/质谱设备的实时控制。