Genetic Dissection of the NADPH Metabolic Network

NADPH 代谢网络的基因剖析

• 批准号: 341466-2012
• 负责人: Merritt, Thomas
• 金额: $ 2.04万
• 依托单位: Laurentian University of Sudbury
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=527319
• 关键词: Genetic; Dissection; NADPH; Metabolic; Network

All organisms, be they flies or people, have physical characteristics (phenotypes) that are, in part, a function of their genetic material, their genotype. These phenotypes are what distinguish one organism from the next and can be as innocuous as eye color or as biologically crucial as basic metabolism or response to a particular drug. Modern science is very good at determining genotype, reading an organism's genetic material, but still working on connecting genotype to phenotype. My research seeks to better explain this connection in biological networks - using the interacting genes and proteins of a metabolic network as a model system.

所有的生物体，无论是苍蝇还是人，都有物理特征（表型），这些物理特征在一定程度上是其遗传物质（基因型）的功能。 这些表型是区分一个生物体与下一个生物体的关键，它们可以像眼睛的颜色一样无害，也可以像基本代谢或对特定药物的反应一样具有生物学意义。现代科学非常擅长确定基因型，阅读有机体的遗传物质，但仍致力于将基因型与表型联系起来。我的研究旨在更好地解释生物网络中的这种联系-使用代谢网络中相互作用的基因和蛋白质作为模型系统。