Probing chemical change at the plasma membrane

探测质膜的化学变化

• 批准号: 341732-2010
• 负责人: Cairo, Christopher
• 金额: $ 2.19万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=527439
• 关键词: Probing; chemical; change; plasma; membrane

The primary conduit of information between the environment and the machinery of a cell are the components of the cell membrane. Participants in this process allow the cell to adapt and react to its surroundings and also allow cells to communicate with each other. Cell surface receptors are integral membrane proteins that can communicate information through mechanisms that include chemical, voltage, and conformational changes in addition to the transport of small molecules. Receptors are universally appreciated for this essential role in biology; however, due to their embedding in the cell membrane these structures have proven to be difficult to study in molecular detail.

细胞膜的组成部分是环境和细胞机器之间的主要信息通道。这个过程的参与者允许细胞适应和对周围环境做出反应，并允许细胞相互交流。细胞表面受体是一种整合的膜蛋白，除了小分子的转运外，还可以通过化学、电压和构象变化等机制传递信息。受体因其在生物学中的重要作用而受到普遍重视;然而，由于它们嵌入细胞膜中，这些结构已被证明难以在分子细节上进行研究。