Computational methods in modelling fibre-reinforced soft biological tissues

纤维增强软生物组织建模的计算方法

• 批准号: 371443-2009
• 负责人: Federico, Salvatore
• 金额: $ 2.04万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=528214
• 关键词: Computational; methods; modelling; fibre; reinforced

My research focuses on the mechanical properties of soft biological tissues, and the investigation of their response to external stimuli, growth, adaptation, failure, degeneration. I am particularly interested in the development of theoretical models of soft tissues, in order to predict their mechanical and physical properties, based on tissue microstructure. The theoretical approach is based on descriptions of a certain system by means of a set of equations. In several cases, these equations can be used analytically to find important basic relationships between physical quantities. However, there are cases in which the equations are so complex that it is impossible to derive any result directly. Furthermore, theoretical models cannot be directly used to solve specific problems characterised by complex geometry and/or boundary conditions (for example, the mechanics of a biological joint, with bones, articular cartilage, ligaments, etc).

我的研究重点是生物软组织的力学特性，以及它们对外界刺激的反应，生长，适应，失败，退化的调查。我特别感兴趣的软组织的理论模型的发展，以预测其机械和物理性能，基于组织的微观结构。理论方法是基于通过一组方程对某个系统的描述。在某些情况下，这些方程可以用于分析，以找到物理量之间的重要基本关系。然而，在某些情况下，方程是如此复杂，以至于不可能直接导出任何结果。此外，理论模型不能直接用于解决以复杂几何形状和/或边界条件为特征的特定问题（例如，具有骨骼、关节软骨、韧带等的生物关节的力学）。