Novel surface modification technique for chemically inert polymers for medical and biomedical applications
用于医疗和生物医学应用的化学惰性聚合物的新型表面改性技术
基本信息
- 批准号:372048-2009
- 负责人:
- 金额:$ 1.6万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2013
- 资助国家:加拿大
- 起止时间:2013-01-01 至 2014-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Thermoplastic polymers such as poly(ethylene terephthalate) and polypropylene are flexible, resilient, durable, and resist biological degradation. It is these properties that make such polymers desirable for medical uses such as surgical drapes, sutures, vascular grafts and ligament prostheses. However, the hydrophobic surfaces of these polymers can cause medical complications such as thrombosis when their use brings them in contact with blood, or when they are implanted into the human body. Often certain specific applications, such as surgical drapes, will require specialized functions such as antimicrobial surfaces to decrease the possibility of cross-infection in hospitals. Therefore, surface property engineering to either add functions to the substrate polymers or to improve their biocompatibility becomes an important task in the field of medical textiles, biomaterials and biomedical science. The proposed study will develop a novel non-destructive, effective and efficient modification technique for chemically inert thermoplastic polymers. Polymers with functional groups, such as hydroxyls, will be immobilized onto the surfaces of thermoplastic polymers by the formation of an interpenetrating network. To further engineer the surface property, polymer brush architectures can be attached to the surface using a "grafting from" technique after converting the immobilized functional group into proper co-initiator or initiator. Experimental techniques will be explored for the characterization of the formed interpenetrating network and the results correlated to the immobilization efficiency and surface property of the modified materials. The proposed study will lead to a breakthrough in the science of surface modification of chemically inert polymeric materials, which is essential for their applications as medical textiles, biomaterials, and medical devices. The results of the studies can also be used to provide technical support to industries providing protective equipments, medical devices and biomaterials. The proposed work will lead to the training of highly qualified personnel with interdisciplinary skills in Polymer Chemistry, Analytic Chemistry, Medical Textile and Biomaterial Science.
热塑性聚合物,如聚(对苯二甲酸乙酯)和聚丙烯是灵活的,有弹性的,耐用的,并抗生物降解。正是这些特性使这种聚合物在医疗用途上非常理想,如外科手术帷帐、缝合线、血管移植物和韧带假体。然而,当这些聚合物与血液接触或植入人体时,它们的疏水表面会引起诸如血栓等医学并发症。通常某些特定的应用,如手术窗帘,将需要专门的功能,如抗菌表面,以减少医院交叉感染的可能性。因此,为基体聚合物添加功能或改善其生物相容性的表面性能工程成为医用纺织品、生物材料和生物医学领域的重要课题。本研究将为化学惰性热塑性聚合物开发一种新的、无损的、有效的、高效的改性技术。具有官能团的聚合物,如羟基,将通过形成互穿网络固定在热塑性聚合物的表面上。为了进一步设计表面性能,在将固定的官能团转化为适当的共引发剂或引发剂后,可以使用“接枝”技术将聚合物刷结构附着在表面上。实验技术将用于表征形成的互穿网络,以及与改性材料的固定效率和表面性能相关的结果。本研究将在化学惰性高分子材料的表面改性方面取得突破性进展,对其在医用纺织品、生物材料和医疗器械等领域的应用具有重要意义。研究结果还可用于为提供防护设备、医疗器械和生物材料的行业提供技术支持。这项工作将培养具有高分子化学、分析化学、医用纺织和生物材料科学跨学科技能的高素质人才。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Liu, Song其他文献
Understanding Drug Sensitivity and Tackling Resistance in Cancer.
了解癌症的药物敏感性和应对耐药性。
- DOI:
10.1158/0008-5472.can-21-3695 - 发表时间:
2022-04-15 - 期刊:
- 影响因子:11.2
- 作者:
Tyner, Jeffrey W.;Haderk, Franziska;Kumaraswamy, Anbarasu;Baughn, Linda B.;Van Ness, Brian;Liu, Song;Marathe, Himangi;Alumkal, Joshi J.;Bivona, Trever G.;Chan, Keith Syson;Druker, Brian J.;Hutson, Alan D.;Nelson, Peter S.;Sawyers, Charles L.;Willey, Christopher D. - 通讯作者:
Willey, Christopher D.
Hydrogen-rich saline mediates neuroprotection through the regulation of endoplasmic reticulum stress and autophagy under hypoxia-ischemia neonatal brain injury in mice
富氢盐水通过调节内质网应激和自噬介导小鼠缺氧缺血新生儿脑损伤的神经保护作用
- DOI:
10.1016/j.brainres.2016.06.020 - 发表时间:
2016-09-01 - 期刊:
- 影响因子:2.9
- 作者:
Bai, Xuemei;Liu, Song;Wang, Zhen - 通讯作者:
Wang, Zhen
Comparable transforming growth factor beta-mediated immune suppression in ex vivo-expanded natural killer cells from cord blood and peripheral blood: implications for adoptive immunotherapy.
- DOI:
10.1016/j.jcyt.2022.04.001 - 发表时间:
2022-08 - 期刊:
- 影响因子:4.5
- 作者:
Chaudhry, Kajal;Dowlati, Ehsan;Long, Mark D.;Geiger, Ashley;Lang, Haili;Gomez, Eduardo C.;Muniraj, Nethaji;Sanchez, Carlos E.;Singh, Prashant K.;Liu, Song;Bollard, Catherine M.;Cruz, Conrad Russell Y. - 通讯作者:
Cruz, Conrad Russell Y.
Effect and mechanism of oyster hydrolytic peptides on spatial learning and memory in mice.
牡蛎水解肽对小鼠空间学习记忆的影响及机制
- DOI:
10.1039/c7ra13139a - 发表时间:
2018-02-02 - 期刊:
- 影响因子:3.9
- 作者:
Wang, Xueqin;Yu, Huahua;Xing, Ronge;Liu, Song;Chen, Xiaolin;Li, Pengcheng - 通讯作者:
Li, Pengcheng
A Computational Biology Study on the Structure and Dynamics Determinants of Thermal Stability of the Chitosanase from Aspergillus fumigatus.
- DOI:
10.3390/ijms24076671 - 发表时间:
2023-04-03 - 期刊:
- 影响因子:5.6
- 作者:
Wang, Qian;Liu, Song;Li, Kecheng;Xing, Ronge;Chen, Xiaolin;Li, Pengcheng - 通讯作者:
Li, Pengcheng
Liu, Song的其他文献
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{{ truncateString('Liu, Song', 18)}}的其他基金
Development of Functional Materials for Battling Bacterial Contamination
对抗细菌污染的功能材料的开发
- 批准号:
RGPIN-2019-06094 - 财政年份:2022
- 资助金额:
$ 1.6万 - 项目类别:
Discovery Grants Program - Individual
Development of Functional Materials for Battling Bacterial Contamination
对抗细菌污染的功能材料的开发
- 批准号:
RGPIN-2019-06094 - 财政年份:2021
- 资助金额:
$ 1.6万 - 项目类别:
Discovery Grants Program - Individual
Rechargeable potent antiviral facemasks with a novel quaternized N-chloramine (Lab2Market)
含有新型季铵化 N-氯胺的可充电强效抗病毒口罩 (Lab2Market)
- 批准号:
571238-2022 - 财政年份:2021
- 资助金额:
$ 1.6万 - 项目类别:
Idea to Innovation
Development of Functional Materials for Battling Bacterial Contamination
对抗细菌污染的功能材料的开发
- 批准号:
RGPIN-2019-06094 - 财政年份:2020
- 资助金额:
$ 1.6万 - 项目类别:
Discovery Grants Program - Individual
Development of Functional Materials for Battling Bacterial Contamination
对抗细菌污染的功能材料的开发
- 批准号:
RGPIN-2019-06094 - 财政年份:2019
- 资助金额:
$ 1.6万 - 项目类别:
Discovery Grants Program - Individual
Surface Engineering of Chemically Inert Polymers for Medical and Biomedical Applications
用于医疗和生物医学应用的化学惰性聚合物的表面工程
- 批准号:
RGPIN-2014-04922 - 财政年份:2018
- 资助金额:
$ 1.6万 - 项目类别:
Discovery Grants Program - Individual
New anti-biofilm formulations and products
新的抗生物膜配方和产品
- 批准号:
532621-2018 - 财政年份:2018
- 资助金额:
$ 1.6万 - 项目类别:
Engage Grants Program
Surface Engineering of Chemically Inert Polymers for Medical and Biomedical Applications
用于医疗和生物医学应用的化学惰性聚合物的表面工程
- 批准号:
RGPIN-2014-04922 - 财政年份:2017
- 资助金额:
$ 1.6万 - 项目类别:
Discovery Grants Program - Individual
Surface Engineering of Chemically Inert Polymers for Medical and Biomedical Applications
用于医疗和生物医学应用的化学惰性聚合物的表面工程
- 批准号:
RGPIN-2014-04922 - 财政年份:2016
- 资助金额:
$ 1.6万 - 项目类别:
Discovery Grants Program - Individual
Surface Engineering of Chemically Inert Polymers for Medical and Biomedical Applications
用于医疗和生物医学应用的化学惰性聚合物的表面工程
- 批准号:
RGPIN-2014-04922 - 财政年份:2015
- 资助金额:
$ 1.6万 - 项目类别:
Discovery Grants Program - Individual
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