Collective Molecular Dynamic in proteins and membranes

蛋白质和膜的集体分子动力学

• 批准号: 372586-2009
• 负责人: Rheinstadter, Maikel
• 金额: $ 2.04万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=528550
• 关键词: Collective; Molecular; Dynamic; proteins; membranes

Even that biological membranes have been studied for decades, very few biologically relevant processes could be revealed on a molecular level. The reason is the combination of very small nanometer length scales and at the same time very fast dynamics of pico- and nanoseconds, which poses particular experimental challenges. The dynamics involve processes from fast motions of lipid molecules and small protein groups to slow conformational changes of large membrane areas and of membrane embedded proteins. Biological materials are therefore considered as "multi-scale" materials and in order to fully characterize the fluctuations experiments must cover an as large as possible range of length and time scales. This issue can only be addressed by using multiple physical techniques and instruments. We propose to combine neutron, x-ray and light scattering techniques to conduct "broadband membrane and protein spectroscopy".

即使生物膜已经研究了几十年，但在分子水平上很少有生物相关的过程可以揭示。原因是非常小的纳米长度尺度和同时非常快的皮科和纳秒动力学的结合，这带来了特殊的实验挑战。动力学涉及从脂质分子和小蛋白质组的快速运动到大膜面积和膜嵌入蛋白质的缓慢构象变化的过程。因此，生物材料被认为是“多尺度”材料，为了充分表征波动，实验必须涵盖尽可能大的长度和时间尺度范围。这个问题只能通过使用多种物理技术和工具来解决。我们建议结合联合收割机中子，X射线和光散射技术进行“宽带膜和蛋白质光谱学”。