Crosstalk between inhibitory and excitatory neurotransmitter systems during synapse development in the brain

大脑突触发育过程中抑制性和兴奋性神经递质系统之间的串扰

基本信息

  • 批准号:
    408044-2011
  • 负责人:
  • 金额:
    $ 3.5万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2013
  • 资助国家:
    加拿大
  • 起止时间:
    2013-01-01 至 2014-12-31
  • 项目状态:
    已结题

项目摘要

Synapses are key sites of neuronal communication in the brain. They are highly specialized structures with complex molecular machinery that enables the process of chemical neurotransmission to occur. Recent evidence suggests that early signaling through the neurotransmitter GABA, may serve to sculpt brain connectivity. However, the molecular and cellular events that underlie this process remain poorly understood. In this Discovery Grant proposal, we will confront several unresolved issues with respect to the function of early GABA signaling and its role in regulating synaptic connectivity. First, we will determine how early GABA transmission controls glutamate synapse formation using advanced molecular manipulations, high resolution confocal microscopy, and electrophysiology techniques. Our preliminary data suggests that early signaling through the neurotransmitter GABA controls the number of excitatory synapses on developing hippocampal neurons. Next, we will monitor the development of GABA synapses on neurons and define their relationship to developing glutamate synapses. Finally, we will investigate the molecular and cellular processes that govern early GABA signaling. This Discovery Grant project will provide excellent conceptual and technical training for students interested in understanding the development of brain circuitry. The data produced by these students will also create novel insight into mechanisms that control the process of synapse formation.
突触是大脑中神经元交流的关键部位。它们是高度专业化的结构,具有复杂的分子机制,使化学神经传递过程得以发生。最近的证据表明,通过神经递质GABA发出早期信号可能有助于塑造大脑的连通性。然而,这一过程背后的分子和细胞事件仍然知之甚少。在这项发现拨款提案中,我们将面临关于早期GABA信号的功能及其在调节突触连接中的作用的几个悬而未决的问题。首先,我们将使用先进的分子操作、高分辨率共聚焦显微镜和电生理学技术来确定早期GABA传递如何控制谷氨酸突触的形成。我们的初步数据表明,通过神经递质GABA发出的早期信号控制着发育中的海马神经元上兴奋性突触的数量。接下来,我们将监测神经元上GABA突触的发育,并确定它们与谷氨酸突触发育的关系。最后,我们将研究控制早期GABA信号的分子和细胞过程。这一发现资助项目将为对了解大脑回路发展感兴趣的学生提供极好的概念和技术培训。这些学生产生的数据还将为控制突触形成过程的机制创造新的见解。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Murai, Keith其他文献

Murai, Keith的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Murai, Keith', 18)}}的其他基金

Investigating Astrocyte Heterogeneity in the Brain
研究大脑中星形胶质细胞的异质性
  • 批准号:
    RGPIN-2022-03395
  • 财政年份:
    2022
  • 资助金额:
    $ 3.5万
  • 项目类别:
    Discovery Grants Program - Individual
Powering the Brain: Understanding how Astrocytes Contribute to Energy Maintenance
为大脑提供动力:了解星形胶质细胞如何有助于能量维持
  • 批准号:
    RGPIN-2016-05463
  • 财政年份:
    2021
  • 资助金额:
    $ 3.5万
  • 项目类别:
    Discovery Grants Program - Individual
Powering the Brain: Understanding how Astrocytes Contribute to Energy Maintenance
为大脑提供动力:了解星形胶质细胞如何有助于能量维持
  • 批准号:
    RGPIN-2016-05463
  • 财政年份:
    2020
  • 资助金额:
    $ 3.5万
  • 项目类别:
    Discovery Grants Program - Individual
Powering the Brain: Understanding how Astrocytes Contribute to Energy Maintenance
为大脑提供动力:了解星形胶质细胞如何有助于能量维持
  • 批准号:
    RGPIN-2016-05463
  • 财政年份:
    2019
  • 资助金额:
    $ 3.5万
  • 项目类别:
    Discovery Grants Program - Individual
Powering the Brain: Understanding how Astrocytes Contribute to Energy Maintenance
为大脑提供动力:了解星形胶质细胞如何有助于能量维持
  • 批准号:
    RGPIN-2016-05463
  • 财政年份:
    2018
  • 资助金额:
    $ 3.5万
  • 项目类别:
    Discovery Grants Program - Individual
Powering the Brain: Understanding how Astrocytes Contribute to Energy Maintenance
为大脑提供动力:了解星形胶质细胞如何有助于能量维持
  • 批准号:
    RGPIN-2016-05463
  • 财政年份:
    2017
  • 资助金额:
    $ 3.5万
  • 项目类别:
    Discovery Grants Program - Individual
Powering the Brain: Understanding how Astrocytes Contribute to Energy Maintenance
为大脑提供动力:了解星形胶质细胞如何有助于能量维持
  • 批准号:
    RGPIN-2016-05463
  • 财政年份:
    2016
  • 资助金额:
    $ 3.5万
  • 项目类别:
    Discovery Grants Program - Individual
Crosstalk between inhibitory and excitatory neurotransmitter systems during synapse development in the brain
大脑突触发育过程中抑制性和兴奋性神经递质系统之间的串扰
  • 批准号:
    408044-2011
  • 财政年份:
    2015
  • 资助金额:
    $ 3.5万
  • 项目类别:
    Discovery Grants Program - Individual
Crosstalk between inhibitory and excitatory neurotransmitter systems during synapse development in the brain
大脑突触发育过程中抑制性和兴奋性神经递质系统之间的串扰
  • 批准号:
    408044-2011
  • 财政年份:
    2014
  • 资助金额:
    $ 3.5万
  • 项目类别:
    Discovery Grants Program - Individual
Crosstalk between inhibitory and excitatory neurotransmitter systems during synapse development in the brain
大脑突触发育过程中抑制性和兴奋性神经递质系统之间的串扰
  • 批准号:
    408044-2011
  • 财政年份:
    2012
  • 资助金额:
    $ 3.5万
  • 项目类别:
    Discovery Grants Program - Individual

相似海外基金

Prefrontal cortical microcircuit mechanisms for reciprocal interactions between arousal and ethanol consumption
唤醒和乙醇消耗之间相互作用的前额皮质微电路机制
  • 批准号:
    10567739
  • 财政年份:
    2023
  • 资助金额:
    $ 3.5万
  • 项目类别:
Determining the ultrastructural differences between dually and singly innervated dendritic spines and their changes following glutamate excitotoxicity using Cryo-Electron Tomography
使用冷冻电子断层扫描确定双重和单神经支配的树突棘之间的超微结构差异及其在谷氨酸兴奋性毒性后的变化
  • 批准号:
    10679214
  • 财政年份:
    2023
  • 资助金额:
    $ 3.5万
  • 项目类别:
Supplement to Communication between Networks: Context, Inhibition, and Neuromodulation
网络间通信的补充:情境、抑制和神经调节
  • 批准号:
    10478350
  • 财政年份:
    2022
  • 资助金额:
    $ 3.5万
  • 项目类别:
Developmental neural circuit formation based on the competition between excitatory and inhibitory inputs in the cerebellum
基于小脑兴奋性和抑制性输入之间竞争的发育神经回路形成
  • 批准号:
    22K06784
  • 财政年份:
    2022
  • 资助金额:
    $ 3.5万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Dissecting the interactions between TCR signaling strength and inhibitory pathways
剖析 TCR 信号强度和抑制途径之间的相互作用
  • 批准号:
    10649675
  • 财政年份:
    2022
  • 资助金额:
    $ 3.5万
  • 项目类别:
Dissecting the interactions between TCR signaling strength and inhibitory pathways
剖析 TCR 信号强度和抑制途径之间的相互作用
  • 批准号:
    10895664
  • 财政年份:
    2022
  • 资助金额:
    $ 3.5万
  • 项目类别:
Dissecting the interactions between TCR signaling strength and inhibitory pathways
剖析 TCR 信号强度和抑制途径之间的相互作用
  • 批准号:
    10507695
  • 财政年份:
    2022
  • 资助金额:
    $ 3.5万
  • 项目类别:
Intraspinal circuits supporting synergy between the bladder and urethral sphincter in mice
支持小鼠膀胱和尿道括约肌协同作用的椎内回路
  • 批准号:
    10458072
  • 财政年份:
    2021
  • 资助金额:
    $ 3.5万
  • 项目类别:
Topological bridges between circuits, models, and behavior
电路、模型和行为之间的拓扑桥梁
  • 批准号:
    10208403
  • 财政年份:
    2021
  • 资助金额:
    $ 3.5万
  • 项目类别:
Intraspinal circuits supporting synergy between the bladder and urethral sphincter in mice
支持小鼠膀胱和尿道括约肌协同作用的椎内回路
  • 批准号:
    10662280
  • 财政年份:
    2021
  • 资助金额:
    $ 3.5万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了