Genetic hallmark of susceptible cows through macrophage profiling of MAP infected cows: Johne's-disease-associated SNPs impair macrophage function

通过 MAP 感染奶牛的巨噬细胞分析得出易感奶牛的遗传特征：约尼氏病相关的 SNP 损害巨噬细胞功能

• 批准号: 441719-2012
• 负责人: Gévry, Nicolas
• 金额: $ 1.69万
• 依托单位: Université de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=534053
• 关键词: Genetic; hallmark; susceptible; cows; through

Johne's disease (JD) is a debilitating and chronic enteritis in ruminants caused by an intracellular pathogen called Mycobacterium avium ssp. paratuberculosis (MAP). JD causes significant economic losses in the Canadian dairy industry, estimated at $15-$90 million annually. Research is ongoing to identify early and more accurate markers; improvement of host disease resistance using a judicious genetic selection strategy is also an important strategy of the dairy industry. In the present research proposal, we will study cow's macrophages which are a type of specialized antigen presenting immune cells responsible for the engulfment of pathogens.

约翰氏病（JD）是由一种细胞内病原体鸟分枝杆菌引起的反刍动物慢性肠炎。副结核病（MAP）。JD给加拿大乳制品行业造成了巨大的经济损失，估计每年损失1500万至9000万美元。研究正在进行中，以确定早期和更准确的标记;使用明智的遗传选择策略提高宿主疾病抗性也是乳制品行业的重要策略。在本研究计划中，我们将研究牛的巨噬细胞，这是一种专门的抗原呈递免疫细胞，负责吞噬病原体。