Diagnosing Chromosomal Translocations in Solid Tumours

诊断实体瘤中的染色体易位

• 批准号: nhmrc : 1114016
• 负责人: A/Pr Timothy Mercer
• 金额: $ 28.07万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Development Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/diagnosing-chromosomal-translocations-solid-tumours/663300
• 关键词: Diagnosing; Chromosomal; Translocations; Solid; Tumours

Mis-repair of broken chromosomes can fuse together genes that then cause cancer. Current clinical tests are only capable of detecting single well-known gene fusions and are incapable of identifying new fusion events or fusion variations. We have developed a diagnostic technology, termed CaptureSeq, that is capable of finding all fusion genes in a patient sample. In this grant, we will demonstrate the use and advantages of CaptureSeq for diagnosing fusion genes in cancer patients.

对断裂染色体的错误修复可以将基因融合在一起，然后导致癌症。目前的临床测试仅能够检测单个已知的基因融合，并且不能鉴定新的融合事件或融合变异。我们开发了一种名为CaptureSeq的诊断技术，能够找到患者样本中的所有融合基因。在这项资助中，我们将展示CaptureSeq在诊断癌症患者融合基因方面的用途和优势。