Diagnosing Chromosomal Translocations in Solid Tumours

对断裂染色体的错误修复可以将基因融合在一起，然后导致癌症。目前的临床测试仅能够检测单个已知的基因融合，并且不能鉴定新的融合事件或融合变异。我们开发了一种名为CaptureSeq的诊断技术，能够找到患者样本中的所有融合基因。在这项资助中，我们将展示CaptureSeq在诊断癌症患者融合基因方面的用途和优势。

Mis-repair of broken chromosomes can fuse together genes that then cause cancer. Current clinical tests are only capable of detecting single well-known gene fusions and are incapable of identifying new fusion events or fusion variations. We have developed a diagnostic technology, termed CaptureSeq, that is capable of finding all fusion genes in a patient sample. In this grant, we will demonstrate the use and advantages of CaptureSeq for diagnosing fusion genes in cancer patients.