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Biosurface modification using nanoparticles to manage infected dentin

使用纳米粒子修饰生物表面来管理受感染的牙本质

基本信息

批准号：
459022-2013
负责人：
Kishen, Anil
金额：
$ 1.82万
依托单位：
University of Toronto
依托单位国家：
加拿大
项目类别：
Engage Grants Program
财政年份：
2013
资助国家：
加拿大
起止时间：
2013-01-01 至 2014-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=542129
关键词：
Biosurface modification using nanoparticles manage

项目摘要

Dental caries is the most common disease of oral cavity caused by bacteria. Despite the improvements in the restorative treatment, the prevalence of recurrent caries is on the rise. Attempts to prevent caries progression in the developed world have also been of prime focus in order to reduce the prevalence of caries. Recently the treatment of carious lesions has been based on minimally invasive options. Certain specific goals have been outlined for this minimally invasive treatment options: arrest of the active carious lesions, ability to remineralize the filling-dentin interface, stabilization of the infected dentin and minimal removal of tissue for the placement of restorations. In this project we propose the possibility of developing antibacterial nanoparticles with ability to improve filling-dentin interface and block patent dentinal tubules to achieve the key therapeutic requirements in the minimally invasive management of dental caries. This nanoparticles based approach has the potential to enhance treatment outcomes in the minimally invasive management of dental caries. The current research will initiate interaction and develop close collaboration between an industry (Germiphene Corporation) that produces and supplies restorative material/tooth varnish with the University of Toronto researchers who have the expertise in multifunctional nanoparticles.

龋病是由细菌引起的口腔最常见的疾病。尽管在修复治疗方面取得了进步，但复发性龋齿的患病率仍在上升。在发达国家，预防龋齿进展的尝试也是主要焦点，以减少龋齿的患病率。最近，龋损的治疗已经基于微创选择。已经概述了这种微创治疗方案的某些特定目标：阻止活动性龋损、使填充物-牙本质界面再矿化的能力、受感染牙本质的稳定性以及最小限度地去除组织以放置牙本质。在这个项目中，我们提出了开发抗菌纳米颗粒的可能性，能够改善填充牙本质界面和封闭未闭牙本质小管，以实现微创治疗龋齿的关键治疗要求。这种基于纳米颗粒的方法有可能提高龋齿微创治疗的效果。目前的研究将启动互动和发展之间的密切合作的行业（Germiphene公司），生产和供应修复材料/牙齿保护漆与多伦多大学的研究人员谁拥有多功能纳米粒子的专业知识。