Biosurface modification using nanoparticles to manage infected dentin

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Dental caries is the most common disease of oral cavity caused by bacteria. Despite the improvements in the restorative treatment, the prevalence of recurrent caries is on the rise. Attempts to prevent caries progression in the developed world have also been of prime focus in order to reduce the prevalence of caries. Recently the treatment of carious lesions has been based on minimally invasive options. Certain specific goals have been outlined for this minimally invasive treatment options: arrest of the active carious lesions, ability to remineralize the filling-dentin interface, stabilization of the infected dentin and minimal removal of tissue for the placement of restorations. In this project we propose the possibility of developing antibacterial nanoparticles with ability to improve filling-dentin interface and block patent dentinal tubules to achieve the key therapeutic requirements in the minimally invasive management of dental caries. This nanoparticles based approach has the potential to enhance treatment outcomes in the minimally invasive management of dental caries. The current research will initiate interaction and develop close collaboration between an industry (Germiphene Corporation) that produces and supplies restorative material/tooth varnish with the University of Toronto researchers who have the expertise in multifunctional nanoparticles.