INTEGRATION OF BIOMECHANICAL LOADING IN 3D TISSUE GRAFTS AND NOVEL MATERIALS DEVELOPMENT

通用力学试验系统（Instron）已经成为许多研究领域不可缺少的设备。自1946年Instron -带有应变计测力传感器的通用试验机首次问世以来，它已成为生物力学研究的主力，提供了检查和测量生物力学响应力的能力，为研究人员探索开辟了数量惊人的新领域，并使他们能够更好地理解和量化生物和工程系统中的应力-应变关系。这些影响包括发现了生物系统中结构与功能的关系以及仿生生物材料的发展。这些系统和方法的最新进展使研究人员能够可视化和测量动态事件。 所要求的通用测试系统将用ElectroPulsr E1000取代我们退役的通用测试系统。退役通用试验机是Instron 4301。它在实验室中运行了30多年，由于不可替代的部件故障而不得不退役。所要求的系统将与我们在过去二十年中设计的现有夹具兼容，用于适当安装样本，以可靠地对各种生物材料（尤其是牙科植入物）进行疲劳测试。该系统将位于II级生物安全实验室附近，并与牙科学院的先进显微镜/成像设施集成。这将是一个独特的设施，进行生物力学研究的体外组织移植物和原位硬组织。该系统将得到我们现有用户群的支持。该设施将允许PI和共同申请人研究静态和动态生物力学事件，以更好地了解硬组织和合成生物材料。Kishen博士研究三维组织移植物和牙本质组织，Bozec博士研究胶原蛋白结构和生物力学特性，Changoor博士研究骨关节炎中的软骨生物力学，Manolson博士研究骨质疏松症中的骨生物力学，Santerre博士研究自由基生成的聚氨酯化学，其提供了嵌段共聚物的化学多样性，相分离以形成分子间结构域结构的能力，从而产生影响细胞功能的物理线索，以推动创新的新型聚合物生物材料开发计划。Dr. Prachiro探索组织再生中的DNA支架，Dr. Prakki描述修复牙科材料的特征。在每一种情况下，理解的改善推动基础研究，促进我们的HQP高度参与的学习环境，同时支持我们与工业和研究合作伙伴的互动。与申请人合作的38名HQP以及其他牙科学院PI和合作机构的其他数字需要使用该设备。

The universal mechanical testing system (Instron) as we know today has been an indispensable equipment across many fields of research. Since the first incarnation of Instron - Universal Testing Machines with strain gauge load cells in 1946 it has become the workhorse for biomechanical research providing the ability to inspect and measure biomechanical response forces, opening up a staggering number of new areas for researchers to explore and allowing them to better understand and quantify stress-strain relationship in biological and engineered systems. Among the impacts was the discovery of the relationship between structure and function in biological system and development of biomimetic biomaterials. Recent advances in these systems and approaches has enabled researchers to visualize and measure dynamic events. The requested Universal testing system will replace our decommissioned universal testing system, with the ElectroPulsr E1000. The decommission universal testing machine is an Instron 4301. It operational in the lab for more than 30 years and had to be decommissioned due to an irreplaceable part failure. The requested system will be compatible with our existing fixtures that have been designed over the last two decades for mounting samples appropriately to perform fatigue testing reliably on various biomaterials, especially dental implants. This system will be located adjacent to the Class II biosafety labs and integrated with the advanced microscopy/imaging facilities at the Faculty of Dentistry. This will be a unique facility to conduct biomechanical studies on in-vitro tissue grafts and in-situ hard tissues. The system will be supported by our current user base. This facility will allow the PIs and co-applicants to study static and dynamic biomechanical events to gain an improved understanding of hard tissues and synthetic biomaterials. Dr. Kishen investigates three-dimensional tissue grafts and dentin tissue, Dr. Bozec studies collagen structural and biomechanical properties, Dr. Changoor studies cartilage biomechanical in Osteoarthritis, Dr. Manolson investigates bone biomechanics in Osteoporosis, Dr. Santerre studies free radical generated polyurethane chemistry, which affords the chemical diversity of block copolymers, the ability to phase separate to form intermolecular domain structures to yield physical cues that influence cell function, to drive a program on innovative new polymeric biomaterials development. Dr. Carneiro explores DNA scaffolds in tissue regeneration, Dr. Prakki characterizes restorative dental materials. In each case improvements in understanding drive fundamental research, promoting highly engaging learning environment for our HQPs while supporting our interactions with industrial and research partners. 38 HQPs working with the applicants and additional numbers from other Faculty of Dentistry PIs and collaborating institutes require access to this equipment.