Detection of blood volume change in brain by analyzing bioimpedance spectroscopy

通过分析生物阻抗谱检测大脑血容量变化

• 批准号: 460755-2013
• 负责人: Shirmohammadi, Shervin
• 金额: $ 0.91万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Engage Plus Grants Program
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=542278
• 关键词: Detection; blood; volume; change; brain

Neurostimulation is a promising method used for treatment of various neurological disorders such as depression, epilepsy, stroke, addiction and pain. However most of the existing neurostimulation techniques need surgical implantation of the stimulation electrodes. Therefore, developing a noninvasive neurostimulation method is a necessity to improve clinical therapy of brain related disorders. To be fully automated, such a system needs a classification scheme in order to analyze the feedback data and detect brain conditions. In this proposed project, we will work with Nuraleve Inc. to use a data set of measurement of head BioImpedance Spectroscopy, with the electrodes in different positions based on a number of simulations that Nuraleve has performed to model the current propagation in the skull, scalp and brain. We plan to analyse this collected data to detect positions and also acquire some insights on how to interpret BIS measurements with a classifier.

神经刺激是一种很有前途的方法，用于治疗各种神经系统疾病，如抑郁症，癫痫，中风，成瘾和疼痛。然而，大多数现有的神经刺激技术需要手术植入刺激电极。因此，开发一种无创性神经刺激方法是改善脑相关疾病临床治疗的必要条件。为了实现完全自动化，这样的系统需要一个分类方案，以便分析反馈数据并检测大脑状况。在这个项目中，我们将与Nuraleve Inc.合作。使用头部生物阻抗谱测量的数据集，电极位于不同位置，基于Nuraleve进行的大量模拟，以模拟颅骨，头皮和大脑中的电流传播。我们计划分析这些收集的数据来检测位置，并获得一些关于如何使用分类器解释BIS测量的见解。