Architectural and mechanical determinates of motor unit recruitment in mammalian muscle

哺乳动物肌肉运动单位募集的结构和机械决定因素

• 批准号: 261262-2008
• 负责人: Wakeling, James
• 金额: $ 1.75万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=547703
• 关键词: Architectural; mechanical; determinates; motor; unit

Vertebrates use their different muscles for specific movements, and that they select the muscles that are mechanically most appropriate for each task. Motor units are the functional contractile units within each muscle and there are good mechanical reasons to suggest that the different motor units should also be used in a mechanically appropriate manner. We have recently developed the techniques necessary to determine which types of motor unit are active within a muscle during movements and locomotion. These have enabled us to demonstrate, for the first time, that faster motor units can be preferentially used for faster contractions. This finding is a paradigm shift away from traditional explanations of recruitment patterns. However, the evidence suggests that there must be other factors that are important and necessary for determining the recruitment patterns within a muscle but these are poorly understood for locomotor situations.

脊椎动物用不同的肌肉来完成特定的动作，它们会选择最适合每项任务的肌肉。运动单元是每块肌肉内的功能性收缩单元，有很好的机械理由表明，不同的运动单元也应该以机械上适当的方式使用。我们最近开发了必要的技术，以确定在运动和运动过程中肌肉中哪些类型的运动单元是活跃的。这使我们第一次证明，更快的运动单元可以优先用于更快的收缩。这一发现是对招聘模式的传统解释的范式转变。然而，有证据表明，在确定肌肉内的招募模式时，必须有其他重要和必要的因素，但这些因素在运动情况下知之甚少。