Structural and control mechanisms for generating force and power from whole muscles
从整个肌肉产生力量和动力的结构和控制机制
基本信息
- 批准号:RGPIN-2015-03966
- 负责人:
- 金额:$ 2.4万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2016
- 资助国家:加拿大
- 起止时间:2016-01-01 至 2017-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Muscle models that enable accurate and reliable assessment of in vivo motor function, rigorously tested in animal and human studies, have broad application to human health and life-long mobility. Recent models of muscle force production show that we still have much to learn about how whole muscles generate force during daily activities. The long-term goal of this research program is to translate the complex mechanisms of muscle recruitment and structural interactions into refined muscle models that can predict in vivo function more accurately. Identifying the mechanisms that contribute to whole-muscle function will enhance our ability to study and maintain human health and mobility. The results from this work will have direct application to computational representations of muscles during analysis of movement, and will be utilized by biomechanists, biomedical engineers and health professionals.
The 3D paths of muscle fibres, their interactions with surrounding connective tissue and the forces produced by the whole muscle are all affected by the way in which the fibres bulge during contraction. We will investigate the causal mechanisms, and the consequences of, the transverse bulging of the fibres. During daily activities, only a fraction of the muscle fibres are activated during each contraction. Recent evidence showed how the presence of inactive fibres affects the contractile properties of whole muscle; we will test whether this is due to the dynamic properties of this inactive tissue. The mechanics of a limb depends on the interaction and coordination of all the muscles in the limb. We will test the effect of muscle coordination on efficiency during cycling. This research program will have an impact on Natural Sciences and Engineering through the development of new tools and technologies, and through our novel scientific findings. We will (1) develop novel ultrasound-based imaging techniques to quantify fascicle bulging in 3D during voluntary contraction, (2) develop and validate 3D finite element models of contracting muscle with both experimentally measured forces, and the internal 3D geometry of the muscle fibres, and (3) develop a feed-back system that allows muscle coordination to be changed in real-time. These new tools will be applied to address novel scientific questions about (A) the effect of muscle structure on whole-muscle function, (B) the role of the dynamics of inactive tissue in the whole muscle, and (C) mechanisms relating muscle coordination to the mechanical output of the leg.
肌肉模型能够准确可靠地评估体内运动功能,并在动物和人体研究中经过严格测试,在人类健康和终身活动能力方面具有广泛的应用。最近的肌肉力量产生模型表明,我们仍然需要了解整个肌肉在日常活动中如何产生力量。这项研究计划的长期目标是将肌肉募集和结构相互作用的复杂机制转化为可以更准确地预测体内功能的精细肌肉模型。确定有助于整个肌肉功能的机制将提高我们研究和维护人类健康和流动性的能力。这项工作的结果将直接应用于运动分析过程中肌肉的计算表示,并将被生物力学家,生物医学工程师和健康专业人员所利用。
肌肉纤维的3D路径,它们与周围结缔组织的相互作用以及整个肌肉产生的力都受到纤维在收缩过程中膨胀的方式的影响。我们将调查的因果机制,和后果,横向膨胀的纤维。在日常活动中,每次收缩时只有一小部分肌肉纤维被激活。最近的证据表明,无活性纤维的存在如何影响整个肌肉的收缩特性;我们将测试这是否是由于这种无活性组织的动态特性。肢体的力学取决于肢体中所有肌肉的相互作用和协调。我们将测试肌肉协调对骑自行车效率的影响。这项研究计划将通过开发新的工具和技术,并通过我们的新的科学发现对自然科学和工程产生影响。我们将(1)开发新的基于超声的成像技术,以量化自愿收缩过程中的3D肌束膨胀,(2)开发和验证收缩肌肉的3D有限元模型,包括实验测量的力和肌肉纤维的内部3D几何形状,以及(3)开发一个反馈系统,允许肌肉协调实时改变。这些新工具将被应用于解决新的科学问题:(A)肌肉结构对整个肌肉功能的影响,(B)整个肌肉中非活性组织的动力学作用,以及(C)肌肉协调与腿部机械输出相关的机制。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Wakeling, James其他文献
Effect of velocity on shoulder muscle recruitment patterns during wheelchair propulsion in nondisabled individuals: Pilot study
- DOI:
10.1682/jrrd.2011.03.0047 - 发表时间:
2012-01-01 - 期刊:
- 影响因子:0
- 作者:
Qi, Liping;Wakeling, James;Ferguson-Pell, Martin - 通讯作者:
Ferguson-Pell, Martin
Coordination patterns of shoulder muscles during level-ground and incline wheelchair propulsion
- DOI:
10.1682/jrrd.2012.06.0109 - 发表时间:
2013-01-01 - 期刊:
- 影响因子:0
- 作者:
Qi, Liping;Wakeling, James;Ferguson-Pell, Martin - 通讯作者:
Ferguson-Pell, Martin
Changes in surface electromyography signals and kinetics associated with progression of fatigue at two speeds during wheelchair propulsion
- DOI:
10.1682/jrrd.2011.01.0009 - 发表时间:
2012-01-01 - 期刊:
- 影响因子:0
- 作者:
Qi, Liping;Wakeling, James;Ferguson-Pell, Martin - 通讯作者:
Ferguson-Pell, Martin
A method for quantifying dynamic muscle dysfunction in children and young adults with cerebral palsy
- DOI:
10.1016/j.gaitpost.2006.06.009 - 发表时间:
2007-04-01 - 期刊:
- 影响因子:2.4
- 作者:
Wakeling, James;Delaney, Roisin;Dudkiewicz, Israel - 通讯作者:
Dudkiewicz, Israel
Wakeling, James的其他文献
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{{ truncateString('Wakeling, James', 18)}}的其他基金
Internal mechanics of whole muscle contraction
全肌肉收缩的内部机制
- 批准号:
RGPIN-2020-07015 - 财政年份:2022
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
Internal mechanics of whole muscle contraction
全肌肉收缩的内部机制
- 批准号:
RGPIN-2020-07015 - 财政年份:2021
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
Internal mechanics of whole muscle contraction
全肌肉收缩的内部机制
- 批准号:
RGPIN-2020-07015 - 财政年份:2020
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
Structural and control mechanisms for generating force and power from whole muscles
从整个肌肉产生力量和动力的结构和控制机制
- 批准号:
RGPIN-2015-03966 - 财政年份:2019
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
Structural and control mechanisms for generating force and power from whole muscles
从整个肌肉产生力量和动力的结构和控制机制
- 批准号:
RGPIN-2015-03966 - 财政年份:2018
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
The effect of custom-made orthotics on foot muscle activity**
定制矫形器对足部肌肉活动的影响**
- 批准号:
536424-2018 - 财政年份:2018
- 资助金额:
$ 2.4万 - 项目类别:
Engage Grants Program
Structural and control mechanisms for generating force and power from whole muscles
从整个肌肉产生力量和动力的结构和控制机制
- 批准号:
RGPIN-2015-03966 - 财政年份:2017
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
Structural and control mechanisms for generating force and power from whole muscles
从整个肌肉产生力量和动力的结构和控制机制
- 批准号:
RGPIN-2015-03966 - 财政年份:2015
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
Architectural and mechanical determinates of motor unit recruitment in mammalian muscle
哺乳动物肌肉运动单位募集的结构和机械决定因素
- 批准号:
261262-2008 - 财政年份:2014
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
Architectural and mechanical determinates of motor unit recruitment in mammalian muscle
哺乳动物肌肉运动单位募集的结构和机械决定因素
- 批准号:
261262-2008 - 财政年份:2013
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
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