SPECTRAL SIGNATURES OF CHIRALITY AND CHIRALITY RECOGNITION

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A molecule is chiral, or said to exhibit "handedness", if its mirror image cannot be superimposed onto itself. Research into chirality and chirality recognition would be a pure scientific adventure if not for this important fact: many of the molecules produced by organisms exhibit a specific handedness. While one mirror image that fits the intended receptor in the organism is active, the other one may be inactive or may cause severe harm. There are, however, significant challenges in evaluating and finding solutions to these implications since the mirror images are so similar in many ways! My research program is dedicated to provide answers to two main aspects of these challenges through developments of 1) fast reliable methods for chirality determination and 2) rigorous chirality recognition models at the molecular level.