Chirality and Chirality Recognition

手性和手性识别

• 批准号: CRC-2017-00347
• 负责人: Xu, Yunjie
• 金额: $ 14.57万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=694286
• 关键词: Chirality; Recognition

A molecule is chiral if its mirror image cannot be superimposed onto itself. Chirality is ubiquitous in biological systems and essential for life. By creatively combining diverse areas of chiral science into her research program, Xu aims to provide answers to many challenges in chiral chemistry. Her team will design and execute original and innovative experiments to quantify intermolecular interactions responsible for chirality recognition/transfer/amplification in isolated molecular clusters, in solution, and at liquid/liquid interfaces. The research outcome will be important for developing a broad range of chiral technologies from sensors for pharmaceutical processes to novel catalysts for chiral drug syntheses.

如果一个分子的镜像不能叠加到其自身上，则该分子是手性的。手性在生物系统中普遍存在，对生命至关重要。通过创造性地将手性科学的不同领域结合到她的研究项目中，徐的目标是为手性化学中的许多挑战提供答案。她的团队将设计并执行原创和创新实验，以量化负责孤立分子簇、溶液中和液/液界面中手性识别/转移/放大的分子间相互作用。该研究成果对于开发从制药过程传感器到手性药物合成的新型催化剂等广泛的手性技术非常重要。