SPECTRAL SIGNATURES OF CHIRALITY AND CHIRALITY RECOGNITION

手性的光谱特征和手性识别

• 批准号: 262983-2013
• 负责人: Xu, Yunjie
• 金额: $ 6.12万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=594784
• 关键词: SPECTRAL; SIGNATURES; CHIRALITY; RECOGNITION

A molecule is chiral, or said to exhibit "handedness", if its mirror image cannot be superimposed onto itself. Research into chirality and chirality recognition would be a pure scientific adventure if not for this important fact: many of the molecules produced by organisms exhibit a specific handedness. While one mirror image that fits the intended receptor in the organism is active, the other one may be inactive or may cause severe harm. There are, however, significant challenges in evaluating and finding solutions to these implications since the mirror images are so similar in many ways! My research program is dedicated to provide answers to two main aspects of these challenges through developments of 1) fast reliable methods for chirality determination and 2) rigorous chirality recognition models at the molecular level.

如果一个分子的镜像不能叠加到其自身上，则该分子是手性的，或者说表现出“手性”。如果没有这个重要的事实，对手性和手性识别的研究将是一个纯粹的科学冒险：生物体产生的许多分子都表现出特定的手性。当一个镜像适合生物体中的预期受体时，另一个镜像可能是无活性的或可能造成严重伤害。然而，由于镜像在许多方面是如此相似，因此在评估和找到这些影响的解决方案方面存在重大挑战！我的研究项目致力于通过开发1）快速可靠的手性测定方法和2）分子水平上严格的手性识别模型来解决这些挑战的两个主要方面。