SPECTRAL SIGNATURES OF CHIRALITY AND CHIRALITY RECOGNITION

一个分子是手性的，或者说是表现出“手性”，如果它的镜像不能叠加到它自己上。如果没有这个重要的事实：生物体产生的许多分子都表现出特定的手性，那么对手性和手性识别的研究将是一项纯粹的科学冒险。当一个与生物体中预期受体相匹配的镜像是活跃的，另一个可能是不活跃的或可能造成严重的伤害。然而，在评估和找到这些影响的解决方案方面存在重大挑战，因为镜像在许多方面是如此相似！我的研究计划致力于通过开发1)快速可靠的手性测定方法和2)分子水平上严格的手性识别模型来解决这些挑战的两个主要方面。

A molecule is chiral, or said to exhibit "handedness", if its mirror image cannot be superimposed onto itself. Research into chirality and chirality recognition would be a pure scientific adventure if not for this important fact: many of the molecules produced by organisms exhibit a specific handedness. While one mirror image that fits the intended receptor in the organism is active, the other one may be inactive or may cause severe harm. There are, however, significant challenges in evaluating and finding solutions to these implications since the mirror images are so similar in many ways! My research program is dedicated to provide answers to two main aspects of these challenges through developments of 1) fast reliable methods for chirality determination and 2) rigorous chirality recognition models at the molecular level.