Chirality and Chirality Recognition

手性和手性识别

• 批准号: CRC-2017-00347
• 负责人: Xu, Yunjie
• 金额: $ 14.57万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=669100
• 关键词: Chirality; Recognition

A molecule is chiral if its mirror image cannot be superimposed onto itself. Chirality is ubiquitous in biological systems and essential for life. By creatively combining diverse areas of chiral science into her research program, Xu aims to provide answers to many challenges in chiral chemistry. Her team will design and execute original and innovative experiments to quantify intermolecular interactions responsible for chirality recognition/transfer/amplification in isolated molecular clusters, in solution, and at liquid/liquid interfaces. The research outcome will be important for developing a broad range of chiral technologies from sensors for pharmaceutical processes to novel catalysts for chiral drug syntheses.

如果一个分子的镜像不能与其自身重叠，那么它就是手性分子。手性在生物系统中无处不在，是生命所必需的。通过创造性地将手性科学的不同领域结合到她的研究项目中，徐旨在为手性化学中的许多挑战提供答案。她的团队将设计和执行原创和创新的实验，以量化分子间的相互作用，负责手性识别/转移/扩增在孤立的分子簇，在溶液中，并在液/液界面。该研究成果将对开发广泛的手性技术具有重要意义，从制药过程的传感器到手性药物合成的新型催化剂。