Canadian resource center for zebrafish genetics

加拿大斑马鱼遗传学资源中心

• 批准号: 311857-2009
• 负责人: Ekker, Marc
• 金额: $ 6.45万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Major Resources Support Program - Infrastructure
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=548529
• 关键词: Canadian; resource; center; zebrafish; genetics

The zebrafish has become one of the most widely used species for the study of vertebrate development due to its characteristics that facilitate embryological analyses and the fact that large-scale genetic approaches are possible. The number of Canadian investigators using zebrafish has grown rapidly over the last few years. This increase created the need for a centralized resource center. We propose to establish a resource center that will serve the entire Canadian community of investigators using zebrafish. Some activities of the center will take place at the University of Ottawa and others at the University of Alberta. The many benefits from such a resource center for the community include the distribution of zebrafish strains, transgenic lines, and mutants, along with the distribution of genomics materials such genotyping reagents and chromosome mapping panels. The resource center will also provide training for students and other trainees who need to learn advanced experimental techniques. Finally, the resource center will be the site of multi-investigator genetics projects such as screens for novel mutations affecting specific genes, screen for small molecules with biological activity. Such projects are often too large and costly to be carried out by individual laboratories but are amenable to groups of investigators who use a common facility. The national zebrafish resource center will facilitate studies in developmental genetics in several Canadian laboratories and will contribute to the continued increase in the research involving this important model system.

斑马鱼已成为脊椎动物发育研究中最广泛使用的物种之一，因为它的特性，有利于胚胎学分析和事实，大规模的遗传方法是可能的。在过去的几年里，使用斑马鱼的加拿大研究人员的数量迅速增长。这种增长产生了对集中资源中心的需求。 我们建议建立一个资源中心，为整个加拿大使用斑马鱼的研究人员提供服务。该中心的一些活动将在渥太华大学举行，其他活动将在阿尔伯塔大学举行。这样一个资源中心对社区的许多好处包括分布斑马鱼品系、转基因品系和突变体，沿着分布基因组学材料，如基因分型试剂和染色体作图板。资源中心还将为需要学习先进实验技术的学生和其他受训人员提供培训。 最后，资源中心将成为多研究者遗传学项目的场所，如筛选影响特定基因的新突变，筛选具有生物活性的小分子。这些项目往往太大，费用太高，无法由单个实验室进行，但可以由使用共同设施的研究小组进行。 国家斑马鱼资源中心将促进几个加拿大实验室的发育遗传学研究，并将有助于继续增加涉及这一重要模式系统的研究。