Regulation of solute and water balance in primitive fishes

原始鱼类溶质和水平衡的调节

• 批准号: 311909-2010
• 负责人: Anderson, WGary
• 金额: $ 1.97万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=548554
• 关键词: Regulation; solute; water; balance; primitive

Endocrine control of solute and water balance is a life sustaining process in all organisms. It requires the coordinated action of a number of different physiological systems through the interaction of a multitude of hormones. Hormones such as angiotensin II, C-type natriuretic peptide, bradykinin and arginine vasotocin are all involved in solute and water regulation in mammals. Research has shown that these hormones also exist, and have physiological function, in the phylogenetically ancient elasmobranch fish. The proposed research programme will examine the role these hormones play in the regulation of renal, cardiovascular and gastro-intestinal physiology of elasmobranch fish. In addition, molecular characterisation of key transport proteins for urea and ammonia will provide new information on nitrogen balance in elasmobranchs. Furthermore, the role ureolytic bacteria may play in nitrogen metabolism in these primitive fish will be examined. The proposed research is significant as it aims to provide an evolutionary framework for solute transport mechanisms in vertebrates and a physiological understanding of how hormone systems regulate similar physiological functions in elasmobranch fish. Additional research is proposed to examine calcium transport and the endocrine regulation of this key ion in a second primitive fish, the lake sturgeon. These freshwater cartilaginous fish present a unique model in terms of calcium regulation. Molecular characterisation of transport mechanisms in addition to hormonal regulation of this ion will aid in our understanding of calcium metabolism in these fish and therefore the proposed research will aid in the mitigation of potential impacts in the documented declines of environmental calcium may have on this threatened species. Therefore, information gained from this proposed research programme can be used not only in the context of industry as this fundamental research underpins more advanced and innovative research in the development of therapeutics in the pharmaceutical industry but also from the context of conservation physiology for the protection of threatened species such as the lake sturgeon.

内分泌对溶质和水分平衡的控制是所有生物体维持生命的一个过程。它需要许多不同的生理系统通过多种激素的相互作用协同作用。血管紧张素II、c型利钠肽、缓激肽、精氨酸缩宫素等激素均参与哺乳动物溶质和水分调节。研究表明，这些激素也存在，并具有生理功能，在系统发育古老的板鳃鱼。拟议的研究计划将检查这些激素在调节板鳃鱼的肾脏、心血管和胃肠道生理方面所起的作用。此外，尿素和氨的关键转运蛋白的分子特征将为研究弹性枝的氮平衡提供新的信息。此外，我们还将进一步研究这些原始鱼类的溶尿细菌在氮代谢中的作用。该研究旨在为脊椎动物的溶质转运机制提供一个进化框架，并从生理学角度理解激素系统如何调节板鳃鱼的类似生理功能。研究人员建议进一步研究第二种原始鱼类湖鲟的钙转运和这一关键离子的内分泌调节。这些淡水软骨鱼在钙调节方面呈现出一种独特的模式。除了激素调节外，转运机制的分子特征将有助于我们了解这些鱼类的钙代谢，因此拟议的研究将有助于减轻环境钙含量下降可能对这些受威胁物种的潜在影响。因此，从这项拟议的研究计划中获得的信息不仅可以用于工业背景，因为这项基础研究为制药工业中治疗学的发展提供了更先进和创新的研究基础，而且还可以用于保护湖泊鲟鱼等濒危物种的保护生理学背景。