Functional characterization of new mouse models for susceptibility to Salmonella infection identified in a genome-wide ENU mutagenesis screen.

在全基因组 ENU 诱变筛选中鉴定出对沙门氏菌感染易感性的新小鼠模型的功能特征。

• 批准号: 291793
• 负责人: Malo Danielle
• 金额: $ 46.96万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-09-01 至 2018-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=291793&lang=en
• 关键词: Cell Sorting; Chemical Mutagenesis; Complementation Assays; Forward Genetics; Global Gene Expression; Immunofluorescence; Immunophenotyping; In Vivo Imaging; Knock Out Technology; Salmonella

Gram-negative bacteria of the genus Salmonella are ubiquitous in nature. They are able of producing a spectrum of clinical disease in both animals and man ranging from asymptomatic carriage to life threatening sepsis. Human infection occurs in two major p

沙门氏菌属的革兰氏阴性细菌在自然界中随处可见。它们能够在动物和人类身上产生一系列临床疾病，从无症状的携带者到危及生命的败血症。人类感染主要发生在两个方面