The molecular basis of sex determination and differentiation in mosquitoes
蚊子性别决定和分化的分子基础
基本信息
- 批准号:312690-2010
- 负责人:
- 金额:$ 1.97万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2014
- 资助国家:加拿大
- 起止时间:2014-01-01 至 2015-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Mosquitoes are the world's most serious disease vectors, with diseases like malaria and dengue killing or causing debilitating illness in millions of people every year. In Canada, the recent mosquito-borne incursion of West Nile Virus poses an as yet undetermined threat to our population, but without appropriate control measures, it could become a more serious problem for both the health and tourism sectors. Aside from their disease transmission potential, mosquitoes are serious nuisance insects and tens of millions of dollars are spent each year in Canada to control these pests. With increasing incidences of insecticide resistance and growing concerns about the adverse affects of these chemicals on non-target species, including humans, we desperately need to find new, preferably pest-specific control methods. In this study, we are examining the processes of sex differentiation in mosquitoes, with the aim of finding new ways to prevent mosquitoes from reproducing. Using molecular genetic techniques, we intend to identify the genes involved in determining the sex of mosquitoes and genes involved in male fertility. Using gene-silencing technologies, we will attempt to develop sterile, all-male lab-bred populations of mosquitoes, which can be used in genetic control programs to reduce pest mosquito populations in genetic sterilization programs, without the use of broad-spectrum pesticides. If genetic control strategies do not prove effective, our screen of genes involved in mosquito reproduction could still provide new targets for new mosquito-specific pesticides. Our identification of genes involved in mosquito fertility may also prove of considerable interest to other research groups examining issues of human fertility, as we will undoubtedly find that some genes are conserved across many species.
蚊子是世界上最严重的疾病媒介,疟疾和登革热等疾病每年导致数百万人死亡或导致虚弱疾病。在加拿大,最近通过蚊子传播的西尼罗河病毒入侵对我们的人口构成了尚未确定的威胁,但如果没有适当的控制措施,它可能会成为卫生和旅游业的一个更严重的问题。除了传播疾病的可能性外,蚊子还是一种严重的滋扰昆虫,加拿大每年花费数千万美元来控制这些害虫。随着杀虫剂抗药性发生率的增加和人们对这些化学物质对包括人类在内的非目标物种的不利影响的日益关注,我们迫切需要找到新的、最好是针对害虫的特定控制方法。在这项研究中,我们正在研究蚊子的性别分化过程,目的是找到防止蚊子繁殖的新方法。利用分子遗传学技术,我们打算确定决定蚊子性别的基因和涉及雄性生育的基因。利用基因沉默技术,我们将尝试培育不育的、全是雄性的实验室培育的蚊子种群,这些蚊子可以用于基因控制计划,以减少基因绝育计划中的害虫蚊子数量,而不需要使用广谱杀虫剂。如果基因控制策略被证明不是有效的,我们对参与蚊子繁殖的基因的筛选仍然可以为新的蚊子特定杀虫剂提供新的靶点。我们对蚊子繁殖相关基因的识别也可能对其他研究人类生育问题的研究小组产生相当大的兴趣,因为我们无疑会发现,一些基因在许多物种中都是保守的。
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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Whyard, Steven其他文献
Ingested double-stranded RNAs can act as species-specific insecticides
- DOI:
10.1016/j.ibmb.2009.09.007 - 发表时间:
2009-11-01 - 期刊:
- 影响因子:3.8
- 作者:
Whyard, Steven;Singh, Aditi D.;Wong, Sylvia - 通讯作者:
Wong, Sylvia
Differential expression of heat shock proteins and antioxidant enzymes in response to temperature, starvation, and parasitism in the Carob moth larvae, Ectomyelois ceratoniae (Lepidoptera: Pyralidae)
- DOI:
10.1371/journal.pone.0228104 - 发表时间:
2020-01-29 - 期刊:
- 影响因子:3.7
- 作者:
Farahani, Saeed;Bandani, Ali R.;Whyard, Steven - 通讯作者:
Whyard, Steven
Whyard, Steven的其他文献
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{{ truncateString('Whyard, Steven', 18)}}的其他基金
The molecular basis of sex differentiation in mosquitoes
蚊子性别分化的分子基础
- 批准号:
RGPIN-2020-05339 - 财政年份:2022
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
The molecular basis of sex differentiation in mosquitoes
蚊子性别分化的分子基础
- 批准号:
RGPIN-2020-05339 - 财政年份:2021
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
The molecular basis of sex differentiation in mosquitoes
蚊子性别分化的分子基础
- 批准号:
RGPIN-2020-05339 - 财政年份:2020
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
RNA interference technologies to protect crop plants
RNA干扰技术保护农作物
- 批准号:
469484-2014 - 财政年份:2017
- 资助金额:
$ 1.97万 - 项目类别:
Collaborative Research and Development Grants
RNAi-based crop protection technology
基于RNAi的作物保护技术
- 批准号:
514830-2017 - 财政年份:2017
- 资助金额:
$ 1.97万 - 项目类别:
Engage Grants Program
RNA interference technologies to protect crop plants
RNA干扰技术保护农作物
- 批准号:
469484-2014 - 财政年份:2016
- 资助金额:
$ 1.97万 - 项目类别:
Collaborative Research and Development Grants
RNA interference technologies to protect crop plants
RNA干扰技术保护农作物
- 批准号:
469484-2014 - 财政年份:2015
- 资助金额:
$ 1.97万 - 项目类别:
Collaborative Research and Development Grants
RNA delivery to mosquito larvae for species-specific control
将 RNA 递送至蚊子幼虫以进行物种特异性控制
- 批准号:
485579-2015 - 财政年份:2015
- 资助金额:
$ 1.97万 - 项目类别:
Engage Grants Program
Advances in control technologies for wood-boring invasive insects
蛀木入侵昆虫防治技术进展
- 批准号:
491898-2015 - 财政年份:2015
- 资助金额:
$ 1.97万 - 项目类别:
Engage Grants Program
Crop protection technologies using RNA interference - a proof-of-concept
利用 RNA 干扰的作物保护技术 - 概念验证
- 批准号:
462649-2014 - 财政年份:2014
- 资助金额:
$ 1.97万 - 项目类别:
Engage Grants Program
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