Combinatorial models and algorithms in bioinformatics

生物信息学中的组合模型和算法

• 批准号: 371978-2010
• 负责人: Manuch, Jan
• 金额: $ 1.82万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=550146
• 关键词: Combinatorial; models; algorithms; bioinformatics

My future research plans call for a continued focus on problems in bioinformatics and computational biology. Besides the theoretical values, results of the proposed research can have significant practical importance. The inverse protein folding problem and in particular hand-in-glove designs have significant relevance for understanding protein interactions and our solutions can help to target new protein designs for disease using in-silico techniques. Our algorithms for haplotyping have drawn the attention of biologists and we believe there is significant potential to help to narrow their search for disease markers. The complexity and algorithmic results on RNA pathway problems help in understanding RNA function in biological settings and in design of programmed molecular systems. Several practical questions we have considered in these various domains have an interdisciplinary character, and they are leasing us to explore exciting connections to fundamental problems in other areas.

我未来的研究计划要求继续关注生物信息学和计算生物学的问题。除了理论价值外，所提出的研究结果可能具有重大的实际意义。逆蛋白质折叠问题，特别是手在手套设计有重要的相关性，了解蛋白质的相互作用，我们的解决方案可以帮助靶向新的蛋白质设计的疾病使用计算机技术。我们的单体型分析算法已经引起了生物学家的注意，我们相信有很大的潜力来帮助缩小他们对疾病标志物的搜索。RNA通路问题的复杂性和算法结果有助于理解RNA在生物环境中的功能和设计程序化的分子系统。我们在这些不同领域考虑的几个实际问题具有跨学科的性质，它们使我们能够探索与其他领域基本问题的令人兴奋的联系。